Reznik G, Mohr U
Abteilung für Experimentelle Pathologie, Medizinische Hochschule Hannover, G.F.R.
Cancer Lett. 1977 Mar;2(4-5):201-7. doi: 10.1016/s0304-3835(77)80022-0.
Up to a 50% rate of thyroid gland tumours was induced in Sprague-Dawley rats after s.c. administration of di-isopropanolnitrosamine (DIPN). The neoplasms occurred both unilaterally and bilaterally, and were identified histologically as adenomas and adenocarcinomas of follicular epithelium origin. In a few instances, adenomas were observed as early as 18 weeks after commencement of treatment. Most adenocarcinomas could be observed macroscopically, and frequently demonstrated infiltration into the surrounding muscles.
皮下注射二异丙基亚硝胺（DIPN）后，高达50%的斯普拉格-道利大鼠诱发了甲状腺肿瘤。肿瘤可单侧或双侧发生，组织学上鉴定为滤泡上皮起源的腺瘤和腺癌。在少数情况下，早在治疗开始后18周就观察到腺瘤。大多数腺癌肉眼可见，且常表现为浸润周围肌肉。
