Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, Nanning, China.
Department of Radiology, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou Worker's Hospital Guangxi Zhuang Autonomous Region, Liuzhou, China.
Front Endocrinol (Lausanne). 2023 Feb 17;14:1140111. doi: 10.3389/fendo.2023.1140111. eCollection 2023.
To investigate the application value of 3T MRI qDixon-WIP technique in the quantitative measurement of pancreatic fat content in patients with type 2 diabetes mellitus (T2DM).
The 3T MRI qDixon-WIP sequence was used to scan the livers and the pancreas of 47 T2DM patients (experimental group) and 48 healthy volunteers (control group). Pancreatic fat fraction (PFF), hepatic fat fraction (HFF), Body mass index (BMI) ratio of pancreatic volume to body surface area (PVI) were measured. Total cholesterol (TC), subcutaneous fat area (SA), triglyceride (TG), abdominal visceral fat area (VA), high density lipoprotein (HDL-c), fasting blood glucose (FPC) and low-density lipoprotein (LDL-c) were collected. The relationship between the experimental group and the control group and between PFF and other indicators was compared. The differences of PFF between the control group and different disease course subgroups were also explored.
There was no significant difference in BMI between the experimental group and the control group (=0.231). PVI, SA, VA, PFF and HFF had statistical differences (<0.05). In the experimental group, PFF was highly positively correlated with HFF (=0.964, <0.001), it was moderately positively correlated with TG and abdominal fat area (=0.676, 0.591, <0.001), and it was weakly positively correlated with subcutaneous fat area (=0.321, =0.033). And it had no correlation with FPC, PVI, HDL-c, TC and LDL-c (>0.05). There were statistical differences in PFF between the control group and the patients with different course of T2DM (<0.05). There was no significant difference in PFF between T2DM patients with a disease course ≤1 year and those with a disease course <5 years (>0.05). There were significant differences in PFF between the groups with a disease course of 1-5 years and those with a disease course of more than 5 years (<0.001).
PVI of T2DM patients is lower than normal, but SA, VA, PFF, HFF are higher than normal. The degree of pancreatic fat accumulation in T2DM patients with long disease course was higher than that in patients with short disease course. The qDixon-WIP sequence can provide an important reference for clinical quantitative evaluation of fat content in T2DM patients.
探讨 3T MRI qDixon-WIP 技术在 2 型糖尿病（T2DM）患者胰腺脂肪含量定量测量中的应用价值。
采用 3T MRI qDixon-WIP 序列扫描 47 例 T2DM 患者（实验组）和 48 例健康志愿者（对照组）的肝脏和胰腺。测量胰腺脂肪分数（PFF）、肝脂肪分数（HFF）、体质量指数（BMI）与胰腺表面积比（PVI）。收集总胆固醇（TC）、皮下脂肪面积（SA）、甘油三酯（TG）、腹部内脏脂肪面积（VA）、高密度脂蛋白（HDL-c）、空腹血糖（FPC）、低密度脂蛋白（LDL-c）。比较实验组与对照组、PFF 与其他指标的关系。还探讨了对照组与不同病程亚组之间 PFF 的差异。
实验组与对照组 BMI 差异无统计学意义（=0.231）。PVI、SA、VA、PFF 和 HFF 差异有统计学意义（<0.05）。实验组 PFF 与 HFF 高度正相关（=0.964，<0.001），与 TG 和腹部脂肪面积中度正相关（=0.676，0.591，<0.001），与皮下脂肪面积弱正相关（=0.321，=0.033），与 FPC、PVI、HDL-c、TC 和 LDL-c 无相关性（>0.05）。对照组与不同病程 T2DM 患者的 PFF 差异有统计学意义（<0.05）。病程≤1 年与病程<5 年的 T2DM 患者 PFF 差异无统计学意义（>0.05）。病程 1-5 年与病程>5 年的患者 PFF 差异有统计学意义（<0.001）。
T2DM 患者的 PVI 低于正常，但 SA、VA、PFF、HFF 高于正常。病程较长的 T2DM 患者胰腺脂肪堆积程度高于病程较短的患者。qDixon-WIP 序列可为 T2DM 患者脂肪含量的临床定量评估提供重要参考。
