Lee Mu Sook, Lee Jeong Sub, Kim Bong Soo, Kim Doo Ri, Kang Ki Soo
Department of Radiology, Keimyung University Dongsan Hospital, Daegu, Korea.
Department of Radiology, Jeju National University Hospital, Jeju National University College of Medicine, Jeju, Korea.
Pediatr Gastroenterol Hepatol Nutr. 2021 Nov;24(6):555-563. doi: 10.5223/pghn.2021.24.6.555. Epub 2021 Nov 5.
The aim of this study was to evaluate the pancreatic fat fraction (PFF) using magnetic resonance imaging (MRI) in children with and without obesity and to correlate PFF with body mass index (BMI) z-score, hepatic fat fraction (HFF), and ultrasonography-derived pancreato-perihepatic fat index (PPHFI).
This prospective study included 45 children with obesity and 19 without obesity (control group). PFF and HFF were quantitatively assessed using the abdominal multi-echo Dixon method for MRI. The PPHFI was assessed using transabdominal ultrasonography. Anthropometric, MRI, and ultrasonographic characteristics were compared between the two groups. Correlations between PFF, HFF, PPHFI, and BMI z-scores in each group were also analyzed.
The PFF, HFF, PPHFI, and BMI z-score were higher in the group with obesity than in the control group (PFF: 6.65±3.42 vs. 1.78±0.55, HFF: 19.5±13.0 vs. 2.31±1, PPHFI: 3.65 ±1.63 vs. 0.94±0.31, BMI z-score: 2.27±0.56 vs. 0.42±0.54, <0.01, respectively). PFF was correlated with BMI z-scores, PPHFI, and HFF in the obesity group, and multivariate analysis showed that PFF was strongly correlated with BMI z-score and PPHFI (<0.05). The BMI z-score was strongly correlated with PFF in the control group (<0.01).
These results suggest that MRI-derived PFF measures are associated with childhood obesity. PFF and PPHFI were also highly correlated in the obesity group. Therefore, PFF may be an objective index of pancreatic fat content and has the potential for clinical utility as a non-invasive biomarker for the assessment of childhood obesity.
本研究旨在利用磁共振成像（MRI）评估肥胖和非肥胖儿童的胰腺脂肪分数（PFF），并将PFF与体重指数（BMI）z评分、肝脏脂肪分数（HFF）以及超声衍生的胰周肝脂肪指数（PPHFI）进行关联分析。
这项前瞻性研究纳入了45名肥胖儿童和19名非肥胖儿童（对照组）。采用腹部多回波狄克逊法对MRI定量评估PFF和HFF。采用经腹超声评估PPHFI。比较两组儿童的人体测量学、MRI和超声特征。同时分析每组中PFF、HFF、PPHFI和BMI z评分之间的相关性。
肥胖组的PFF、HFF、PPHFI和BMI z评分均高于对照组（PFF：6.65±3.42 vs. 1.78±0.55，HFF：19.5±13.0 vs. 2.31±1，PPHFI：3.65 ±1.63 vs. 0.94±0.31，BMI z评分：2.27±0.56 vs. 0.42±0.54，P均<0.01）。肥胖组中PFF与BMI z评分、PPHFI和HFF相关，多因素分析显示PFF与BMI z评分和PPHFI密切相关（P<0.05）。对照组中BMI z评分与PFF密切相关（P<0.01）。
这些结果表明，MRI衍生的PFF测量值与儿童肥胖相关。肥胖组中PFF和PPHFI也高度相关。因此，PFF可能是胰腺脂肪含量的客观指标，有潜力作为评估儿童肥胖的非侵入性生物标志物应用于临床。
