Aliani Fatemeh, Haghshenas Zahra, Vosough Dizaj Ahmad, Arabipoor Arezoo, Vesali Samira, Ashrafi Mahnaz
Department of Pediatrics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Reproductive Imaging, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Int J Reprod Biomed. 2023 Feb 8;21(1):53-60. doi: 10.18502/ijrm.v21i1.12666. eCollection 2023 Jan.
Several studies have been conducted worldwide to evaluate the prevalence and relative risks of congenital anomalies associated with assisted reproductive technology cycles; however, there is limited data in Iran.
To investigate male genital anomalies among live births from assisted reproductive technology.
This cross-sectional study was conducted on children born after intracytoplasmic sperm injection (ICSI) at Royan Institute, Tehran, Iran from April 2013-December 2015. The prevalence of male genitalia disorders that included hypospadias, epispadias, cryptorchidism, micropenis, and vanishing testis were reported. The relationship between the cause of infertility and type of embryo transfer (fresh or frozen), gestational age at birth (term or preterm), and birth weight with these male genitalia anomalies were evaluated.
In total, 4409 pregnant women were followed after their ICSI cycles to evaluate genitalia anomalies in their children. Out of 5608 live births, 2614 (46.61%) newborns were male, of which 14 cases (0.54%) had genital anomalies. The prevalence of various anomalies were cryptorchidism (0.34%), hypospadias (0.038%), micropenis (0.038%), vanishing testis (0.038%), and epispadias (0.077%). No relationship was found between the cause of infertility, type of embryo transfer (fresh or frozen), gestational age at birth (term or preterm), and male genital malformation (p = 0.33, p = 0.66, and p = 0.62, respectively).
The prevalence of each male genital anomaly after the ICSI cycle was rare and less than 0.5%; however, no significant infertility-related factor was observed with these anomalies.
全球已开展多项研究以评估与辅助生殖技术周期相关的先天性异常的患病率和相对风险；然而，伊朗的数据有限。
调查辅助生殖技术活产儿中的男性生殖器异常情况。
本横断面研究对2013年4月至2015年12月在伊朗德黑兰罗扬研究所经卵胞浆内单精子注射（ICSI）后出生的儿童进行。报告了包括尿道下裂、尿道上裂、隐睾症、小阴茎和睾丸消失在内的男性生殖器疾病的患病率。评估了不孕原因与胚胎移植类型（新鲜或冷冻）、出生时的孕周（足月或早产）以及出生体重与这些男性生殖器异常之间的关系。
共有4409名孕妇在ICSI周期后接受随访，以评估其子女的生殖器异常情况。在5608例活产儿中，2614例（46.61%）为男婴，其中14例（0.54%）有生殖器异常。各种异常的患病率分别为隐睾症（0.34%）、尿道下裂（0.038%）、小阴茎（0.038%）、睾丸消失（0.038%）和尿道上裂（0.077%）。未发现不孕原因、胚胎移植类型（新鲜或冷冻）、出生时的孕周（足月或早产）与男性生殖器畸形之间存在关联（p值分别为0.33、0.66和0.62）。
ICSI周期后每种男性生殖器异常的患病率都很低，低于0.5%；然而，未观察到与这些异常相关的显著不孕相关因素。
