Department of Urology, Chongqing Medical University Affiliated Children's Hospital, Chongqing, 400010, China; Children's Hospital of Chongqing Medical University, Chongqing, 400010, China.
Department of Urology, Chongqing Medical University Affiliated Children's Hospital, Chongqing, 400010, China; Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, 400010, China; National Clinical Research Center for Child Health and Disorders, Chongqing, 400010, China; China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, 400010, China; Children's Hospital of Chongqing Medical University, Chongqing, 400010, China; Chongqing Key Laboratory of Pediatrics, Chongqing, 400010, China.
J Pediatr Urol. 2021 Feb;17(1):9-20. doi: 10.1016/j.jpurol.2020.11.005. Epub 2020 Nov 5.
A systematic review was conducted to evaluate the relationship between ART and the risk of urogenital tract malformations, especially hypospadias and cryptorchidism. Thirty-three papers were selected. Meta-analysis showed that ART was correlated with an increased risk of urogenital tract malformation in offspring (odds ratio (OR) = 1.61, 95% confidence interval (CI): 1.41-1.85), hypospadias (OR = 1.87, 95% CI: 1.47-2.40) and cryptorchidism (OR = 1.83, 95% CI: 1.54-2.18). Among offspring conceived by ART, multiple pregnancies appeared to result in a higher risk of urogenital tract malformation than singleton pregnancies (OR = 1.42, 95% CI: 0.99-2.04; P = 0.058). No significant difference in the risk of urogenital tract malformation was found between in vitro fertilization and intracytoplasmic sperm injection technologies. A sensitivity analysis showed that the above conclusions were relatively consistent. Conclusion: ART is correlated with an increased risk of urogenital tract malformations in offspring, especially hypospadias and cryptorchidism. Among ART offspring, multiple pregnancies may lead to a higher risk of urogenital tract malformations than singleton pregnancies, but more studies are needed for confirmation.
一项系统评价评估了 ART 与尿生殖道畸形（尤其是尿道下裂和隐睾）风险之间的关系。共纳入 33 篇文献。Meta 分析显示，ART 与后代发生尿生殖道畸形的风险增加相关（比值比（OR）=1.61，95%置信区间（CI）：1.41-1.85），包括尿道下裂（OR=1.87，95%CI：1.47-2.40）和隐睾（OR=1.83，95%CI：1.54-2.18）。在接受 ART 受孕的后代中，多胎妊娠似乎比单胎妊娠发生尿生殖道畸形的风险更高（OR=1.42，95%CI：0.99-2.04；P=0.058）。体外受精和胞浆内单精子注射技术之间，尿生殖道畸形的风险无显著差异。敏感性分析表明，上述结论相对一致。结论：ART 与后代发生尿生殖道畸形（尤其是尿道下裂和隐睾）的风险增加相关。在接受 ART 受孕的后代中，多胎妊娠可能比单胎妊娠发生尿生殖道畸形的风险更高，但还需要更多的研究来证实。
