Yadav Renu, Kumar Manish, Kumar Niraj, Chacham Swathi
Department of Paediatrics, All India Institute of Medical Sciences, Rishikesh, India.
Department of Paediatrics, All India Institute of Medical Sciences, Gorakhpur, India.
Sudan J Paediatr. 2022;22(2):190-192. doi: 10.24911/SJP.106-1584524803.
Isoniazid is a first-line drug for the management of tuberculosis. Recent changes in paediatric tuberculosis guidelines have insisted on a higher daily dose of isoniazid. Given the burden of paediatric tuberculosis in developing countries, it is pertinent that paediatricians are well versed with all possible adverse effects associated with isoniazid therapy and not just common ones like hepatotoxicity or peripheral neuropathy. Psychosis is one such rare adverse effect which has a reported incidence of 1%-2%. Here, we report a case of isoniazid-induced psychosis in a 4-year-old girl. The purpose of this report is to sensitise the paediatric healthcare community regarding this rare clinical entity along with highlighting the putative role of pyridoxine supplementation in the management of isoniazid-induced psychosis.
异烟肼是治疗结核病的一线药物。近期儿科结核病指南的变化坚持使用更高的异烟肼每日剂量。鉴于发展中国家儿科结核病的负担，儿科医生熟知与异烟肼治疗相关的所有可能不良反应，而不仅仅是像肝毒性或周围神经病变等常见不良反应是很有必要的。精神病是一种罕见的不良反应，报告发生率为1%-2%。在此，我们报告一例4岁女孩异烟肼诱发精神病的病例。本报告的目的是提高儿科医疗界对这种罕见临床病症的认识，并强调维生素B6补充剂在异烟肼诱发精神病管理中的假定作用。
