Marine Bio-pharmaceutical Institute, Naval Medical University, Shanghai, 200433, PR China.
Nanomedicine (Lond). 2020 Mar;15(6):625-641. doi: 10.2217/nnm-2019-0388. Epub 2020 Feb 26.
Cell membranes have been continuously imitated and used for the modification of nanoparticles (NPs) to improve NP biological properties. Cell membrane-coated NPs, where core NPs are wrapped with plasma membrane vesicles, show high biocompatibility, targeting specificity and low side effects. Compared with conventional strategies, this novel approach directly leverages intact and natural functions of cell membranes, instead of replicating these features via synthetic techniques. This top-down technique bestows NPs with enhanced biointerfacing capabilities with potential in the diagnosis and treatment of cancer, infection and other diseases. Herein, we report on the advances in cell membrane-coated NPs, including the preparation process, source cell membranes for wrapping and potential applications of these cell membrane-coated NPs.
细胞膜不断被模仿并用于修饰纳米颗粒（NPs）以改善 NP 的生物学特性。细胞膜包覆的 NPs 是指核心 NPs 被质膜囊泡包裹，具有高生物相容性、靶向特异性和低副作用。与传统策略相比，这种新方法直接利用细胞膜的完整和天然功能，而不是通过合成技术复制这些特性。这种自上而下的技术赋予 NPs 增强的生物界面功能，在癌症、感染和其他疾病的诊断和治疗方面具有潜在应用价值。本文报告了细胞膜包覆 NPs 的进展，包括制备过程、用于包裹的源细胞膜以及这些细胞膜包覆 NPs 的潜在应用。
