Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Pathology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
J Magn Reson Imaging. 2023 Oct;58(4):1303-1313. doi: 10.1002/jmri.28670. Epub 2023 Mar 6.
The volume doubling time (VDT) of breast cancer was most frequently calculated using the two-dimensional (2D) diameter, which is not reliable for irregular tumors. It was rarely investigated using three-dimensional (3D) imaging with tumor volume on serial magnetic resonance imaging (MRI).
To investigate the VDT of breast cancer using 3D tumor volume assessment on serial breast MRIs.
Retrospective.
Sixty women (age at diagnosis: 57 ± 10 years) with breast cancer, assessed by two or more breast MRI examinations. The median interval time was 791 days (range: 70-3654 days).
FIELD STRENGTH/SEQUENCE: 3-T, fast spin-echo T2-weighted imaging (T2WI), single-shot echo-planar diffusion-weighted imaging (DWI), and gradient echo dynamic contrast-enhanced imaging.
Three radiologists independently reviewed the morphological, DWI, and T2WI features of lesions. The whole tumor was segmented to measure the volume on contrast-enhanced images. The exponential growth model was fitted in the 11 patients with at least three MRI examinations. The VDT of breast cancer was calculated using the modified Schwartz equation.
Mann-Whitney U test, Kruskal-Wallis test, Chi-squared test, intraclass correlation coefficients, and Fleiss kappa coefficients. A P-value <0.05 was considered statistically significant. The exponential growth model was evaluated using the adjusted R and root mean square error (RMSE).
The median tumor diameter was 9.7 mm and 15.2 mm on the initial and final MRI, respectively. The median adjusted R and RMSE of the 11 exponential models were 0.97 and 15.8, respectively. The median VDT was 540 days (range: 68-2424 days). For invasive ductal carcinoma (N = 33), the median VDT of the non-luminal type was shorter than that of the luminal type (178 days vs. 478 days). On initial MRI, breast cancer manifesting as a focus or mass lesion showed a shorter VDT than that of a non-mass enhancement (NME) lesion (median VDT: 426 days vs. 665 days).
A shorter VDT was observed in breast cancer manifesting as focus or mass as compared to an NME lesion.
3 TECHNICAL EFFICACY: Stage 2.
乳腺癌的倍增时间（VDT）最常使用二维（2D）直径计算，但对于不规则肿瘤，这种方法并不可靠。使用三维（3D）成像和肿瘤体积对连续磁共振成像（MRI）进行研究则相对较少。
使用连续乳腺 MRI 上的 3D 肿瘤体积评估来研究乳腺癌的 VDT。
回顾性。
60 名女性（诊断时年龄：57±10 岁），经两次或两次以上乳腺 MRI 检查评估。中位间隔时间为 791 天（范围：70-3654 天）。
场强/序列：3T，快速自旋回波 T2 加权成像（T2WI），单次激发回波平面扩散加权成像（DWI）和梯度回波动态对比增强成像。
三位放射科医生独立评估了病变的形态学、DWI 和 T2WI 特征。在对比增强图像上对整个肿瘤进行分割以测量体积。使用至少有 3 次 MRI 检查的 11 名患者拟合指数增长模型。使用修正 Schwartz 方程计算乳腺癌的 VDT。
Mann-Whitney U 检验，Kruskal-Wallis 检验，卡方检验，组内相关系数和 Fleiss kappa 系数。P 值<0.05 被认为具有统计学意义。使用调整后的 R 和均方根误差（RMSE）评估指数增长模型。
初始和最后一次 MRI 上的肿瘤直径中位数分别为 9.7mm 和 15.2mm。11 个指数模型的中位数调整 R 和 RMSE 分别为 0.97 和 15.8。中位 VDT 为 540 天（范围：68-2424 天）。对于浸润性导管癌（N=33），非腔型的中位 VDT 短于腔型（178 天比 478 天）。在初始 MRI 上，表现为焦点或肿块病变的乳腺癌的 VDT 短于非肿块强化（NME）病变（中位 VDT：426 天比 665 天）。
与 NME 病变相比，表现为焦点或肿块的乳腺癌的 VDT 较短。
3 级
2 级。
