Zhang X, Wang C-B, Duan L-H, Long J-J, Xiao P, Wang Y-L, Zhang X-H, Liu Q-Q
Neurorehabilitation Center, Shenzhen Dapeng New District Nan'Ao People's Hospital, Shenzhen, China.
Eur Rev Med Pharmacol Sci. 2023 Feb;27(4):1248-1254. doi: 10.26355/eurrev_202302_31357.
This study aimed to investigate the correlation of serum octapeptide cholecystokinin-8 (CCK-8), substance P (SP), and 5-hydroxytryptryptamine (5-HT) values with depression levels in patients with post-stroke depression (PSD). It also aimed to explore the potential approach for the early diagnosis of PSD.
A correlation research between patients' biochemical indicators and depression levels was performed among 70 stroke patients during hospitalization from June 2021 to February 2022. The 70 stroke patients were selected and divided into post-stroke depression and non-depression groups according to the Hamilton Depression Scale (HAMD) score. The concentrations of CCK-8, SP, and 5-HT in both groups were measured, and the relationship between the values of CCK-8, SP, 5-HT and the depression levels was analyzed.
Among the 70 stroke survivors, 35 were in the depression group and 35 were in the non-depression group. Significant differences were observed in the concentration of CCK-8, SP, and 5-HT between the patients in the depression and non-depression group (p < 0.05). Accompanied by an increase in the depression level, the SP value gradually increased, but the CCK-8 and 5-HT values gradually decreased. Spearman correlation analysis indicated that the order of the correlation between CCK-8, 5-HT, SP, and the depression levels was CCK-8 > SP > 5-HT.
All the CCK-8, SP and 5-HT values were correlated with the depression levels in stroke survivors. Furthermore, the correlation between CCK-8, SP, and post-stroke depression levels was higher than that of 5-HT, suggesting that the early diagnosis of PSD may be reflected more precisely through the detection of CCK-8, and SP values, thus providing potential priority for biochemical detection in the diagnosis of PSD.
本研究旨在探讨血清八肽胆囊收缩素 -8（CCK-8）、P物质（SP）和5-羟色胺（5-HT）值与脑卒中后抑郁（PSD）患者抑郁程度的相关性。同时探索PSD早期诊断的潜在方法。
对2021年6月至2022年2月住院期间的70例脑卒中患者进行了生化指标与抑郁程度的相关性研究。选取70例脑卒中患者，根据汉密尔顿抑郁量表（HAMD）评分分为脑卒中后抑郁组和非抑郁组。检测两组患者CCK-8、SP和5-HT的浓度，并分析CCK-8、SP、5-HT值与抑郁程度的关系。
70例脑卒中幸存者中，抑郁组35例，非抑郁组35例。抑郁组和非抑郁组患者CCK-8、SP和5-HT浓度存在显著差异（p<0.05）。随着抑郁程度加重，SP值逐渐升高，而CCK-8和5-HT值逐渐降低。Spearman相关性分析表明，CCK-8、5-HT、SP与抑郁程度的相关性顺序为CCK-8>SP>5-HT。
CCK-8、SP和5-HT值均与脑卒中幸存者的抑郁程度相关。此外，CCK-8、SP与脑卒中后抑郁程度的相关性高于5-HT，提示通过检测CCK-8和SP值可能更准确地反映PSD的早期诊断，从而为PSD诊断中的生化检测提供潜在的优先选择。
