Department of Rehabilitation, Shenzhen Dapeng New District Nanao People's Hospital, Shenzhen, Guangdong, China.
Department of Rehabilitation, The First Affiliated Hospital, Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
Technol Health Care. 2023;31(6):2355-2361. doi: 10.3233/THC-230506.
At present, the pathogenesis of post-stroke insomnia (PSI) is still inconclusive.
To explore the changes and significance of serum cholecystokinin-8 (CCK-8), substance P (SP), and 5-hydroxytryptamine (5-HT) in patients with PSI.
Ninety-one patients with stroke were selected as the research subjects, and according to the score of the Athens Insomnia Scale (AIS), they were divided into the insomnia group and the non-insomnia group. The serum levels of CCK-8, SP, and 5-HT in the two groups were compared to explore their relationships with PSI.
Among the 91 patients, 56 were in the insomnia group and 35 were in the non-insomnia group, and the incidence of insomnia was 61.5%. There was no significant difference in the serum levels of CCK-8, SP, and 5-HT between the two groups (P= 0.696, 0.980, and 0.809, respectively). One-way analysis of variance showed that there was no significant correlation between the serum levels of CCK-8, SP, 5-HT, and the AIS score (P= 0.7393, 0.9581, and 0.5952, respectively).
The incidence of PSI was relatively high, but it could not be proved that CCK-8, SP, and 5-HT were involved in the pathogenesis of PSI. There might exist other neurotransmitters involved in the pathophysiological process of PSI, which should be further explored.
目前，卒中后失眠（PSI）的发病机制仍不明确。
探讨血清胆囊收缩素-8（CCK-8）、P 物质（SP）和 5-羟色胺（5-HT）在 PSI 患者中的变化及意义。
选择 91 例脑卒中患者作为研究对象，根据雅典失眠量表（AIS）评分将其分为失眠组和非失眠组，比较两组患者血清 CCK-8、SP、5-HT 水平，探讨其与 PSI 的关系。
91 例患者中失眠 56 例，非失眠 35 例，失眠发生率为 61.5%。两组患者血清 CCK-8、SP、5-HT 水平比较，差异均无统计学意义（P=0.696、0.980、0.809）。单因素方差分析结果显示，血清 CCK-8、SP、5-HT 水平与 AIS 评分均无显著相关性（P=0.7393、0.9581、0.5952）。
PSI 发生率相对较高，但不能证明 CCK-8、SP、5-HT 参与了 PSI 的发病机制，可能存在其他神经递质参与 PSI 的病理生理过程，有待进一步探讨。
