Yang Ziying, Hu Yajie, Yue Panpan, Li Huiling, Wu Yuying, Hao Xiang, Peng Feng
Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, MOE Engineering Research Center of Forestry Biomass Materials and Energy, Beijing 100083, China.
JALA Research Center, JALA Group Co. Ltd., Shanghai 200233, China.
Carbohydr Polym. 2023 Jan 1;299:120219. doi: 10.1016/j.carbpol.2022.120219. Epub 2022 Oct 14.
Selenium nanoparticles (SeNPs) have attracted widespread attention, but the poor water dispersibility restricted their applications seriously. Herein, Usnea longissima lichenan decorated selenium nanoparticles (L-SeNPs) were constructed. The formation, morphology, particle size, stability, physicochemical characteristics, and stabilization mechanism of L-SeNPs were investigated via TEM, SEM, AFM, EDX, DLS, UV-Vis, FT-IR, XPS, and XRD. The results indicated that the L-SeNPs displayed orange-red, amorphous, zero-valent, and uniform spherical nanoparticles with an average diameter of 96 nm. Due to the formation of CO⋯Se bonds or the hydrogen bonding interaction (OH⋯Se) between SeNPs and lichenan, L-SeNPs exhibited better heating and storage stability, which kept stable for more than one month at 25 °C in an aqueous solution. The decoration of the SeNPs surface with lichenan endowed the L-SeNPs with superior antioxidant capability, and their free radicals scavenging ability exhibited in a dose-dependent manner. Furthermore, L-SeNPs showed excellent selenium controlled-release performance. In simulated gastric liquids, selenium release kinetics from L-SeNPs followed the Linear superimposition model, which was governed by the polymeric network retardation of macromolecular, while in simulated intestinal liquids, it was well fitted to the Korsmeyer-Peppas model and followed a Fickian mechanism controlled by diffusion.
硒纳米颗粒（SeNPs）已引起广泛关注，但其较差的水分散性严重限制了它们的应用。在此，构建了松萝地衣聚糖修饰的硒纳米颗粒（L-SeNPs）。通过透射电子显微镜（TEM）、扫描电子显微镜（SEM）、原子力显微镜（AFM）、能量色散X射线光谱仪（EDX）、动态光散射（DLS）、紫外可见光谱（UV-Vis）、傅里叶变换红外光谱（FT-IR）、X射线光电子能谱（XPS）和X射线衍射（XRD）对L-SeNPs的形成、形态、粒径、稳定性、理化特性及稳定机制进行了研究。结果表明，L-SeNPs呈现橙红色、无定形、零价且均匀的球形纳米颗粒，平均直径为96nm。由于在SeNPs与地衣聚糖之间形成了CO⋯Se键或氢键相互作用（OH⋯Se），L-SeNPs表现出更好的加热和储存稳定性，在25℃的水溶液中可稳定保存一个多月。地衣聚糖对SeNPs表面的修饰赋予了L-SeNPs优异的抗氧化能力，其自由基清除能力呈剂量依赖性。此外，L-SeNPs表现出优异的硒控释性能。在模拟胃液中，L-SeNPs的硒释放动力学遵循线性叠加模型，该模型受大分子的聚合物网络阻滞作用控制，而在模拟肠液中，其很好地拟合了 Korsmeyer-Peppas 模型，并遵循由扩散控制的菲克机制。
