Department of Pulmonary Medicine, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey.
Department of Biochemistry, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey.
Sleep Breath. 2023 Oct;27(5):1865-1874. doi: 10.1007/s11325-023-02800-9. Epub 2023 Mar 6.
Metrnl, a newly discovered adipokine with significant expression in white adipose tissue, promotes energy expenditure and contributes to the development of cardiovascular disorders. Endocan is a surrogate marker for endothelial dysfunction and is linked to cardiovascular risk factors. Higher cardiovascular morbidity and mortality have been linked to obstructive sleep apnea (OSA). In this study, we investigated the potential of serum Metrnl and endocan as biomarkers to identify patients with OSA who are at increased cardiovascular risk and differentiate them from healthy controls.
The study included the evaluation of serum levels of endocan and Metrnl in individuals with OSA and healthy controls. All participants underwent full polysomnography to evaluate their sleep, and carotid intima-media thickness (CIMT) was measured in each of them.
Patients with OSA (n = 117) had considerably lower levels of Metrnl and significantly higher levels of endocan than controls (n = 59). Once confounding factors were taken into account, both Metrnl and endocan were effective predictors of OSA. Additionally, the severity of OSA, as determined by the apnea-hypopnea index (AHI), was linked to Metrnl and endocan levels. The study also found a significant and independent inverse association between CIMT and Metrnl, along with a positive association with endocan after making multiple adjustments. Furthermore, there was a significant and independent connection between CIMT and AHI.
Based on these findings, Metrnl and endocan have the potential to be valuable markers for identifying patients with OSA who are at increased risk of early vascular damage.
Metrnl 是一种新发现的脂肪因子，在白色脂肪组织中表达丰富，可促进能量消耗，并有助于心血管疾病的发展。Endocan 是内皮功能障碍的替代标志物，与心血管危险因素有关。阻塞性睡眠呼吸暂停（OSA）与更高的心血管发病率和死亡率相关。在这项研究中，我们研究了血清 Metrnl 和 Endocan 作为生物标志物的潜力，以识别心血管风险增加的 OSA 患者，并将其与健康对照组区分开来。
该研究评估了 OSA 患者和健康对照组的血清 Endocan 和 Metrnl 水平。所有参与者均接受了全面的多导睡眠图检查以评估其睡眠情况，并测量了每位参与者的颈动脉内膜中层厚度（CIMT）。
与对照组（n = 59）相比，OSA 患者（n = 117）的 Metrnl 水平明显较低，而 Endocan 水平明显较高。在考虑了混杂因素后，Metrnl 和 Endocan 都是 OSA 的有效预测因子。此外，通过睡眠呼吸暂停-低通气指数（AHI）确定的 OSA 严重程度与 Metrnl 和 Endocan 水平相关。该研究还发现 CIMT 与 Metrnl 呈显著负相关，与 Endocan 呈显著正相关，且在进行多次调整后，这些相关性仍然存在。此外，CIMT 与 AHI 之间存在显著的独立关联。
基于这些发现，Metrnl 和 Endocan 可能是识别心血管早期损害风险增加的 OSA 患者的有价值的标志物。
