Depertmant of Pulmonary Diseases, Health Sciences University Erzurum Regional Education and Research Hospital, 25240, Yakutiye, Erzurum, Turkey.
Depertmant of Pulmonary Diseases, Ağrı State Hospital, Ağrı, Turkey.
Lung. 2020 Apr;198(2):307-314. doi: 10.1007/s00408-020-00327-4. Epub 2020 Jan 20.
Chronic obstructive pulmonary disease (COPD) is a common lung disease characterized by airflow limitation and systemic inflammation. Recently, there has been growing interest in adipose tissue-mediated inflammation in the pathogenesis of COPD. The aim of our study was to determine the relationships between a new adipocytokine, meteorin-like protein (Metrnl), and acute exacerbations of COPD, smoking, and comorbidities.
The study included 313 patients aged 40-65 years in four groups: Group 1: ex-smokers (≥ 20 pack-years) with COPD hospitalized for COPD exacerbation (n = 133), Group 2: current-smokers (≥ 20 pack-years) without COPD (n = 60), Group 3: ex-smokers (≥ 20 pack-years) without COPD (n = 60), and Group 4: never-smokers without COPD (n = 60). Peripheral venous blood samples (5 cc) were collected from all participants. Plasma Metrnl levels were measured using commercial enzyme-linked immunosorbent assay (ELISA) kit.
Mean Metrnl levels were 28.45 ± 11.27 ng/ml in Group 1, 24.34 ± 4.38 ng/ml in Group 2, 18.84 ± 3.8 ng/ml in Group 3, and 19.44 ± 3.92 ng/ml in Group 4. Group 1 had significantly higher mean Metrnl level compared to the other groups (p = 0.006, p = 0.001, p = 0.001). Metrnl level was also significantly higher in Group 2 when compared with Groups 3 and 4 (p = 0.001, p = 0.005). Group 1 patients with diabetes mellitus and coronary artery disease showed significantly lower Metrnl levels compared to other patients in the group (p = 0.001, p = 0.001).
The high Metrnl level in COPD exacerbations and active smoking may be important in balancing the inflammatory response. However, plasma Metrnl levels were found to be lower in COPD patients with comorbidities.
慢性阻塞性肺疾病（COPD）是一种常见的肺部疾病，其特征是气流受限和全身炎症。最近，人们对脂肪组织介导的 COPD 发病机制中的炎症越来越感兴趣。我们的研究目的是确定一种新的脂肪细胞因子——类流星蛋白（Metrnl）与 COPD 急性加重、吸烟和合并症之间的关系。
该研究纳入了四个组的 313 名 40-65 岁患者：第 1 组：因 COPD 加重而住院的 COPD 患者（曾吸烟者，≥20 包年，n=133）；第 2 组：目前吸烟但无 COPD 的患者（曾吸烟者，≥20 包年，n=60）；第 3 组：无 COPD 的曾吸烟者（曾吸烟者，≥20 包年，n=60）；第 4 组：无 COPD 的从不吸烟者（n=60）。所有参与者均采集外周静脉血（5cc）。使用商业酶联免疫吸附试验（ELISA）试剂盒测量血浆 Metrnl 水平。
第 1 组的平均 Metrnl 水平为 28.45±11.27ng/ml，第 2 组为 24.34±4.38ng/ml，第 3 组为 18.84±3.8ng/ml，第 4 组为 19.44±3.92ng/ml。第 1 组的平均 Metrnl 水平明显高于其他组（p=0.006，p=0.001，p=0.001）。与第 3 组和第 4 组相比，第 2 组的 Metrnl 水平也明显更高（p=0.001，p=0.005）。与组内其他患者相比，第 1 组患有糖尿病和冠心病的患者的 Metrnl 水平明显更低（p=0.001，p=0.001）。
COPD 加重和主动吸烟时的高 Metrnl 水平可能对平衡炎症反应很重要。然而，在患有合并症的 COPD 患者中发现血浆 Metrnl 水平较低。
