Yalamarty Satya Siva Kishan, Filipczak Nina, Khan Muhammad Muzamil, Torchilin Vladimir P
Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA.
Faculty of Pharmacy, the Islamia University of Bahawalpur, Pakistan.
J Control Release. 2023 Apr;356:306-315. doi: 10.1016/j.jconrel.2023.02.044. Epub 2023 Mar 9.
With the passage of years and the progress of research on ribonucleic acids, the range of forms in which these molecules have been observed grows. One of them, discovered relatively recently, is circular RNA - covalently closed circles (circRNA). In recent years, there has been a huge increase in the interest of researchers in this group of molecules. It entailed a significant increase in the state of knowledge about them, which in turn caused a dramatic change in their perception. Rather than seeing circular RNAs as curiosities that represent a minor information noise in a cell or a result of RNA misprocessing, they came to be regarded as a common, essential, and potentially extremely useful group of molecules. Nevertheless, the current state of the art of circRNA is full of white cards. A lot of valuable information has been obtained from high-throughput methods to study whole transcriptomes, but many issues related to circular RNAs still need to be clarified. Presumably, each answer obtained will raise several new questions. However, circRNAs have a wealth of potential applications, including therapeutic applications.
随着时间的推移以及对核糖核酸研究的进展，人们观察到这些分子的形式范围不断扩大。其中一种相对较新发现的是环状RNA——共价闭合环（circRNA）。近年来，研究人员对这组分子的兴趣大幅增加。这使得关于它们的知识水平显著提高，进而导致了人们对它们看法的巨大变化。环状RNA不再被视为细胞中代表少量信息噪音的奇闻或RNA错误加工的结果，而是被视为一组常见、重要且可能极其有用的分子。然而，目前环状RNA的技术水平仍充满未知。通过研究全转录组的高通量方法已经获得了许多有价值的信息，但与环状RNA相关的许多问题仍有待澄清。据推测，每一个得到的答案都会引发几个新问题。然而，环状RNA有大量潜在应用，包括治疗应用。
