Nelson K B, Ellenberg J H
Neuroepidemiology, Branche, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
Am J Dis Child. 1987 Dec;141(12):1333-5. doi: 10.1001/archpedi.1987.04460120099045.
We investigated whether infants weighing over 2500 g who had experienced one or more of 14 late pregnancy or birth complications, but who were free of certain signs in the nursery period were at increased risk of cerebral palsy (CP). The signs evaluated were decreased activity after the first day of life, need for incubator care for three or more days, feeding problems, poor suck, respiratory difficulty, or neonatal seizures. More than 90% of the infants weighing over 2500 g had none of these signs. In asymptomatic infants with one or more birth complications, the rate of CP by 7 years of age was 2.3/1000; among asymptomatic infants whose births were uncomplicated, the rate of CP was 2.4/1000. The risk for CP rose with number of abnormal neonatal signs, and children with sustained neonatal abnormalities were at higher risk than those whose abnormalities were transient. Most children with CP did not derive from groups at increased risk. The full-term infant whose birth was complicated but who was free of certain abnormal signs in the newborn period was not at increased risk of CP.
我们调查了体重超过2500克、经历过14种晚期妊娠或分娩并发症中的一种或多种但在新生儿期没有特定体征的婴儿是否患脑瘫（CP）的风险增加。评估的体征包括出生后第一天活动减少、需要在暖箱中护理三天或更长时间、喂养问题、吸吮无力、呼吸困难或新生儿惊厥。超过90%体重超过2500克的婴儿没有这些体征。在有一项或多项出生并发症的无症状婴儿中，7岁时脑瘫的发生率为2.3/1000；在出生无并发症的无症状婴儿中，脑瘫发生率为2.4/1000。患脑瘫的风险随着新生儿异常体征数量的增加而上升，持续性新生儿异常的儿童比异常为暂时性的儿童风险更高。大多数脑瘫儿童并非来自风险增加的群体。出生情况复杂但在新生儿期没有特定异常体征的足月儿患脑瘫的风险并未增加。
