University of Arizona, Tucson, AZ, USA.
University of Arizona, Phoenix, AZ, USA.
Integr Cancer Ther. 2023 Jan-Dec;22:15347354231159322. doi: 10.1177/15347354231159322.
Proteasome inhibitors are the cornerstone of multiple myeloma treatment, but challenges still remain despite the increased survival rates. We conducted a review on the role of curcumin, a natural product, as an adjunct to bortezomib and carfilzomib in preclinical multiple myeloma models. Four studies reviewed showed enhanced anticancer effects when curcumin was combined with bortezomib compared to either treatment alone. Two additional studies showed similar results with carfilzomib. Synergistic mechanisms include inhibition of NF-kB, IL-6-induced signaling pathways, JNK pathway modulation, and increased cell cycle arrest.
蛋白酶体抑制剂是多发性骨髓瘤治疗的基石，但尽管生存率有所提高，仍存在挑战。我们对姜黄素作为硼替佐米和卡非佐米在临床前多发性骨髓瘤模型中的辅助药物的作用进行了综述。综述的四项研究表明，与单独使用任一药物相比，姜黄素与硼替佐米联合使用时具有增强的抗癌作用。另外两项研究也显示了卡非佐米的类似结果。协同机制包括抑制 NF-κB、IL-6 诱导的信号通路、JNK 通路调节以及增加细胞周期停滞。
