Bag Sagar, Burman Mangal Deep, Bhowmik Sudipta
Department of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India.
Mahatma Gandhi Medical Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed to Be University), Pondy-Cuddalore Main Road, Pillayarkuppam, Pondicherry, 607402, India.
Heliyon. 2023 Feb 20;9(3):e13959. doi: 10.1016/j.heliyon.2023.e13959. eCollection 2023 Mar.
G-quadruplex, a structurally unique structure in nucleic acids present all throughout the human genome, has sparked great attention in therapeutic investigations. Targeting G-quadruplex structure is a new strategy for the drug development. Flavonoids are found in almost all dietary plant-based beverages and food products; therefore, they are ingested in significant proportions through the human diet. Although synthetically developed drug molecules are used vigorously but they have various adverse effects. While on the other hand, nature supplies chemically unique scaffolds in the form of distinct dietary flavonoids that are easily accessible, less poisonous, and have higher bioavailability. Because of their great pharmacological effectiveness and minimal cytotoxicity, such low molecular weight compounds are feasible alternatives to synthetic therapeutic medicines. Therefore, from a drug-development point of view, investigation on screening the binding capabilities of quadruplex-interactive small natural compounds like dietary flavonoids are expected to be highly effective, with a particular emphasis on the selectivity towards polymorphic G-quadruplex structures. In this respect, quadruplexes have scintillated research into their potential interaction with these dietary flavonoids. The purpose of this review is to offer an up-to-date close-up look at the research on their interaction with structurally varied dietary flavonoids with the goal of providing newer perspectives to construct novel therapeutic agents for next-generation disease managements.
G-四链体是人类基因组中普遍存在的一种核酸独特结构，在治疗研究中引起了极大关注。靶向G-四链体结构是药物开发的一种新策略。黄酮类化合物几乎存在于所有以植物为基础的膳食饮料和食品中；因此，它们通过人类饮食大量摄入。尽管合成开发的药物分子被大力使用，但它们有各种副作用。另一方面，自然界以独特的膳食黄酮类化合物形式提供化学独特的支架，这些化合物易于获取、毒性较小且生物利用度较高。由于其强大的药理作用和最小的细胞毒性，这类低分子量化合物是合成治疗药物的可行替代品。因此，从药物开发的角度来看，研究筛选膳食黄酮类等四链体相互作用小天然化合物的结合能力有望非常有效，尤其强调对多态性G-四链体结构的选择性。在这方面，四链体激发了对其与这些膳食黄酮类潜在相互作用的研究。本综述的目的是对其与结构多样的膳食黄酮类相互作用的研究进行最新的深入探讨，以期为构建用于下一代疾病管理的新型治疗药物提供新的视角。
