肠道菌群-肠-脑轴在新冠后综合征中的作用。
Role of the microbiota-gut-brain axis in postacute COVID syndrome.
机构信息
School of Veterinary Medicine, University of California, Davis, Davis, California, United States.
School of Medicine, University of California, Davis, Sacramento, California, United States.
出版信息
Am J Physiol Gastrointest Liver Physiol. 2023 Apr 1;324(4):G322-G328. doi: 10.1152/ajpgi.00293.2022. Epub 2023 Mar 7.
Abstract
The COVID-19 pandemic has resulted in the infection of hundreds of millions of individuals over the past 3 years, coupled with millions of deaths. Along with these more acute impacts of infection, a large subset of patients has developed symptoms that collectively comprise "postacute sequelae of COVID-19" (PASC, also known as long COVID), which can persist for months and maybe even years. In this review, we outline the current knowledge on the role of impaired microbiota-gut-brain (MGB) axis signaling in the development of PASC and the potential mechanisms involved, which may lead to a better understanding of disease progression and treatment options in the future.
摘要
在过去的 3 年中，COVID-19 大流行导致数亿人感染，数百万人死亡。除了这些更严重的感染影响外，很大一部分患者出现了一系列共同构成“COVID-19 后急性后遗症”（PASC，也称为长新冠）的症状，这些症状可能持续数月甚至数年。在这篇综述中，我们概述了目前关于受损的微生物群-肠道-大脑（MGB）轴信号在 PASC 发展中的作用及其潜在机制的知识，这可能有助于更好地了解未来疾病的进展和治疗选择。
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