Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center McGovern Medical School, Houston, Texas, USA.
Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center McGovern Medical School, Houston, Texas, USA
Ann Clin Lab Sci. 2023 Jan;53(1):159-163.
Phyllodes tumor (PT) is an uncommon fibroepithelial lesion of the breast. PT can be classified as benign, borderline, and malignant based on semi-quantitative assessment of stromal hypercellularity and overgrowth, cytologic atypia, mitotic activity, tumor border, and presence of malignant heterologous elements. PT is considered malignant by default, if malignant heterologous elements are encountered. The heterologous elements include liposarcoma, angiosarcoma, osteosarcoma, chondrosarcoma, and rhabdomyosarcoma. Malignant PT (MPT) with rhabdomyosarcomatous component is extremely rare, and only a few cases are reported. Here, we present a case of MPT with mixed osteosarcomatous and rhabdomyosarcomatous elements in a 51-year-old female, with review of the literatures and discussion of the differential diagnosis.
叶状肿瘤（PT）是一种罕见的乳腺纤维上皮性病变。PT 可以根据间质细胞增生和过度生长、细胞异型性、有丝分裂活性、肿瘤边界和恶性异源性成分的存在进行半定量评估，分为良性、交界性和恶性。如果遇到恶性异源性成分，PT 默认被认为是恶性的。异源性成分包括脂肪肉瘤、血管肉瘤、骨肉瘤、软骨肉瘤和横纹肌肉瘤。伴有横纹肌肉瘤成分的恶性叶状肿瘤（MPT）极为罕见，仅有少数病例报道。在此，我们报告了一例 51 岁女性的 MPT 伴有混合性骨肉瘤和横纹肌肉瘤成分，并复习了文献，讨论了鉴别诊断。
