Carpenter Matthew, Masood Shahla, Sharma Swati, Makary Raafat, Hatch Parlyn, Marji Noor
Pathology, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Pathology and Laboratory Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Cureus. 2024 Jul 5;16(7):e63915. doi: 10.7759/cureus.63915. eCollection 2024 Jul.
Malignant phyllodes tumors (MPTs) represent the most pernicious type of intralobular stromal proliferation known as a "fibroepithelial lesion" (FEL). They comprise a small fraction of breast malignancies and can present as either a pure MPT or sometimes include a heterologous component (liposarcoma, chondrosarcoma, osteosarcoma, or rhabdomyosarcoma). Of the fraction of MPTs that include heterologous components, very little about those with chondroblastic osteosarcomatous differentiation has been described in the literature. As such, a characteristic staining profile has yet to be established, even though morphological analysis is the cornerstone of diagnosis. The few reported cases have described a poor prognosis. Therefore, we present a case of MPT with chondroblastic osteosarcomatous differentiation to contribute to the dearth of literature examining this entity.
恶性叶状肿瘤（MPTs）是小叶内间质增生最具危害性的类型，被称为“纤维上皮性病变”（FEL）。它们在乳腺恶性肿瘤中占比很小，可表现为单纯的MPT，有时还包括异源性成分（脂肪肉瘤、软骨肉瘤、骨肉瘤或横纹肌肉瘤）。在包含异源性成分的MPT中，关于具有软骨母细胞性骨肉瘤分化的病例，文献报道极少。因此，尽管形态学分析是诊断的基石，但尚未建立特征性的染色图谱。少数已报道的病例预后较差。因此，我们报告一例具有软骨母细胞性骨肉瘤分化的MPT病例，以补充有关该实体研究的文献不足。
