The QUEEN MARY School, Nanchang University, Nanchang, China.
Medical Collage of Hebei University of Engineering, Handan, China.
J Cell Physiol. 2023 May;238(5):866-879. doi: 10.1002/jcp.30989. Epub 2023 Mar 8.
Atherosclerosis (AS), a chronic inflammatory vascular disease with lipid metabolism abnormalities, is one of the major pathological bases of coronary heart disease. As people's lifestyles and diets change, the incidence of AS increases yearly. Physical activity and exercise training have recently been identified as effective strategies for lowering cardiovascular disease (CVD) risk. However, the best exercise mode to ameliorate the risk factors related to AS is not clear. The effect of exercise on AS is affected by the type of exercise, intensity, and duration. In particular, aerobic and anaerobic exercise are the two most widely discussed types of exercise. During exercise, the cardiovascular system undergoes physiological changes via various signaling pathways. The review aims to summarize signaling pathways related to AS in two different exercise types and provide new ideas for the prevention and treatment of AS in clinical practice.
动脉粥样硬化（AS）是一种慢性炎症性血管疾病，伴有脂质代谢异常，是冠心病的主要病理基础之一。随着人们生活方式和饮食习惯的改变，AS 的发病率逐年上升。身体活动和运动训练最近被确定为降低心血管疾病（CVD）风险的有效策略。然而，改善与 AS 相关的危险因素的最佳运动模式尚不清楚。运动对 AS 的影响受运动类型、强度和持续时间的影响。特别是，有氧运动和无氧运动是两种最广泛讨论的运动类型。运动过程中，心血管系统通过多种信号通路发生生理变化。本综述旨在总结两种不同运动类型中与 AS 相关的信号通路，为临床预防和治疗 AS 提供新思路。
