Safari Saeid, Davoodi Poorya, Soltani Afsaneh, Fadavipour Mohammadreza, Rezaeian AhmadReza, Heydari Fateme, Khazeei Tabari Mohammad Amin, Akhlaghdoust Meisam
Functional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence Shahid Beheshti University of Medical Sciences Tehran Iran.
USERN Office, Functional Neurosurgery Research Center Shahid Beheshti University of Medical Sciences Tehran Iran.
Health Sci Rep. 2023 Mar 6;6(3):e1145. doi: 10.1002/hsr2.1145. eCollection 2023 Mar.
Chronic obstructive pulmonary disease (COPD) is a common disease of the lungs known as the third reason for death worldwide. Frequent COPD exacerbations compel health care workers to apply interventions that are not adverse effect free. Accordingly, adding or replacing Curcumin, a natural meal flavoring, may indicate advantages in this era by its antiproliferative and anti-inflammatory effects.
The PRISMA checklist was employed for the systematic review study. On June 3, 2022, PubMed/Medline, Scopus, and Web of Science were searched for studies associated with COPD and Curcumin in the last 10 years. Duplicate or non-English publications and articles with irrelevant titles and abstracts were excluded. Also, preprints, reviews, short communications, editorials, letters to the editor, comments, conference abstracts, and conference papers were not included.
Overall, 4288 publications were found eligible, after the screening, 9 articles were finally included. Among them, one, four, and four in vitro, in vivo, and both in vivo and in vitro research exist respectively. According to the investigations, Curcumin can inhibit alveolar epithelial thickness and proliferation, lessen the inflammatory response, remodel the airway, produce ROS, alleviate airway inflammation, hinder emphysema and prevent ischemic complications.
Consequently, the findings of the current review demonstrate that Curcumin's modulatory effects on oxidative stress, cell viability, and gene expression could be helpful in COPD management. However, for data confirmation, further randomized clinical trials are required.
慢性阻塞性肺疾病（COPD）是一种常见的肺部疾病，是全球第三大致死原因。慢性阻塞性肺疾病频繁急性加重迫使医护人员采取并非没有副作用的干预措施。因此，添加或替代姜黄素（一种天然食用香料）在这个时代可能因其抗增殖和抗炎作用而具有优势。
采用PRISMA清单进行系统评价研究。2022年6月3日，检索了PubMed/Medline、Scopus和Web of Science数据库，以查找过去10年中与慢性阻塞性肺疾病和姜黄素相关的研究。排除重复或非英文出版物以及标题和摘要不相关的文章。此外，预印本、综述、简短通讯、社论、给编辑的信、评论、会议摘要和会议论文均未纳入。
总体而言，共检索到4288篇符合条件的出版物，筛选后最终纳入9篇文章。其中，体外研究1篇、体内研究4篇、体内和体外研究均有4篇。根据研究，姜黄素可以抑制肺泡上皮厚度和增殖，减轻炎症反应，重塑气道，产生活性氧，减轻气道炎症，阻碍肺气肿并预防缺血性并发症。
因此，本综述的结果表明，姜黄素对氧化应激、细胞活力和基因表达的调节作用可能有助于慢性阻塞性肺疾病的管理。然而，为了证实数据，还需要进一步的随机临床试验。
