Student Research Committee, Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Research Center, Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Adv Exp Med Biol. 2021;1327:197-204. doi: 10.1007/978-3-030-71697-4_16.
COVID-19 is now pandemic throughout the world, and scientists are searching for effective therapies to prevent or treat the disease. The combination of curcumin and piperine is a potential option for the management of COVID-19 based on several mechanisms including antiviral, anti-inflammatory, immunomodulatory, antifibrotic, and antioxidant effects. Here, we describe the probable mechanism of curcumin-piperine against COVID-19. Administration of curcumin-piperine combination appears as a potential strategy to counterbalance the pathophysiological features of COVID-19 including inflammation. The optimal dose and duration of curcumin-piperine supplementation should be determined in the future.
COVID-19 现已在全球范围内大流行，科学家们正在寻找有效的治疗方法来预防或治疗这种疾病。姜黄素和胡椒碱的组合是基于抗病毒、抗炎、免疫调节、抗纤维化和抗氧化作用等多种机制，用于管理 COVID-19 的一种潜在选择。在这里，我们描述了姜黄素-胡椒碱对抗 COVID-19 的可能机制。姜黄素-胡椒碱联合用药似乎是一种对抗 COVID-19 的病理生理特征（包括炎症）的潜在策略。未来应确定姜黄素-胡椒碱补充的最佳剂量和持续时间。
