根尖周炎和牙髓炎症中的 microRNA 表达：系统评价。
MicroRNA expression in apical periodontitis and pulpal inflammation: a systematic review.
机构信息
Oral & Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Department of Clinical Science, College of Dentistry, Ajman University, Ajman, United Arab Emirates.
出版信息
PeerJ. 2023 Mar 3;11:e14949. doi: 10.7717/peerj.14949. eCollection 2023.
BACKGROUND
The aim of this systematic review is to determine microRNAs (miRs) that are differently expressed between diseased pulpal and periapical tissues.
DESIGN
This systematic review used PubMed, Scopus, EBSCO, ProQuest, Cochrane database as well as manual searching to extract studies from January 2012 up to February 2022.
RESULTS
A total of 12 studies met the eligibility criteria were included. All selected studies were of case-control type. Twenty-four miRNAs associated with apical periodontitis, 11 were found to be upregulatedand 13 were downregulated. Four out of the 44 miRs associated with pulpal inflammation were upregulated, whereas forty were downregulated. Six miRs, namely hsa-miR-181b, hsa-miR-181c,hsa-miR-455-3p,hsa-miR-128-3p, hsa-miR199a-5p, and hsa-miR-95, exhibited considerable downregulation in both periapical and pulp tissues.
CONCLUSION
MiRs have been investigated for their role in pulpal and periapical biology and may be utilised in diagnostic and therapeutic purposes. Further investigations are required to determine why certain irreversible pulpitis situations progress to apical periodontitis and others do not, based on the various miR expressions. Moreover, clinical and laboratory trials are needed to support this theory.
背景
本系统评价的目的是确定牙髓和根尖周病变组织中差异表达的 microRNAs（miRs）。
设计
本系统评价使用 PubMed、Scopus、EBSCO、ProQuest、Cochrane 数据库以及手动检索，从 2012 年 1 月到 2022 年 2 月提取研究。
结果
共有 12 项符合纳入标准的研究被纳入。所有入选研究均为病例对照研究。与根尖周炎相关的 24 个 miRNA，其中 11 个上调，13 个下调。与牙髓炎症相关的 44 个 miRNA 中有 4 个上调，40 个下调。6 个 miRNA，即 hsa-miR-181b、hsa-miR-181c、hsa-miR-455-3p、hsa-miR-128-3p、hsa-miR199a-5p 和 hsa-miR-95，在根尖周和牙髓组织中均表现出明显下调。
结论
miRs 在牙髓和根尖周生物学中的作用已被研究，可能用于诊断和治疗目的。需要进一步的研究来确定为什么某些不可逆转的牙髓炎情况会发展为根尖周炎，而其他情况则不会，这取决于各种 miR 的表达。此外，需要临床和实验室试验来支持这一理论。
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