Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands.
Eur Thyroid J. 2023 Apr 13;12(3). doi: 10.1530/ETJ-22-0211. Print 2023 Jun 1.
Thyroid hormones play an essential role in regulating whole-body homeostasis. Deiodinases are known to convert thyroid hormone from the prohormone thyroxine (T4) to the bioactive hormone tri-iodothyronine (T3) and convert both T4 and T3 toward their inactive metabolites 3,3',5'-tri-iodothyronine (rT3) and 3,3'-di-iodothyronine (3,3'-T2). Deiodinases are thus important for the regulation of intracellular thyroid hormone concentrations. This is known to be crucial both during development and adult life in regulating thyroid hormone-related gene transcription. This review discusses the importance of liver deiodinases in determining serum and liver thyroid hormone concentrations, liver metabolism and liver disease.
甲状腺激素在调节全身内稳态中起着至关重要的作用。脱碘酶已知可将甲状腺激素从前体甲状腺素（T4）转化为生物活性激素三碘甲状腺原氨酸（T3），并将 T4 和 T3 转化为它们的无活性代谢物 3,3',5'-三碘甲状腺原氨酸（rT3）和 3,3'-二碘甲状腺原氨酸（3,3'-T2）。因此，脱碘酶对于调节细胞内甲状腺激素浓度非常重要。这在发育和成年期调节甲状腺激素相关基因转录中都至关重要。这篇综述讨论了肝脱碘酶在确定血清和肝甲状腺激素浓度、肝代谢和肝病中的重要性。
