Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Medical University Eye Hospital, No. 251, Fukang Road, Nankai District, Tianjin 300384, China; Tianjin International Joint Research and Development Centre of Ophthalmology and Vision Science, Tianjin Medical University Eye Hospital, No. 251, Fukang Road, Nankai District, Tianjin 300384, China; Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, No. 251, Fukang Road, Nankai District, Tianjin 300384, China.
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Medical University Eye Hospital, No. 251, Fukang Road, Nankai District, Tianjin 300384, China; Tianjin International Joint Research and Development Centre of Ophthalmology and Vision Science, Tianjin Medical University Eye Hospital, No. 251, Fukang Road, Nankai District, Tianjin 300384, China; Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, No. 251, Fukang Road, Nankai District, Tianjin 300384, China; Department of Ophthalmology, Tianjin Children's Hospital (Children's Hospital of Tianjin University), China.
Exp Gerontol. 2023 May;175:112138. doi: 10.1016/j.exger.2023.112138. Epub 2023 Mar 24.
Diabetic retinopathy (DR) is a leading cause of blindness worldwide and a costly complication of diabetes mellitus (DM). DR severity is associated with DM duration; thus, DR has become more devastating to individuals and healthcare systems owing to the aging population and the significantly increased human lifespan. Aging is an irreversible cellular state characterized by long-term stagnation of the cell cycle from excessive stress or damage. Furthermore, aging plays a critical role in developing age-related diseases, but its effects (direct or indirect) on DR development remain considerably understudied. Nonetheless, some studies have demonstrated that aging-related degeneration and DR development share common risk factors, which helps explain the increased prevalence of DR and visual impairment in the elderly population. This review aims to provide some conceptual insight into aging and DR development, two intertwined pathophysiological processes, and discusses potential therapeutic strategies for DR, including prevention and treatment, during this era of longevity.
糖尿病视网膜病变（DR）是全球范围内导致失明的主要原因，也是糖尿病（DM）的一种昂贵并发症。DR 的严重程度与 DM 的持续时间有关；因此，由于人口老龄化和人类寿命显著延长，DR 对个人和医疗保健系统的破坏性更大。衰老是一种不可逆的细胞状态，其特征是细胞周期因长期过度压力或损伤而停滞不前。此外，衰老在形成与年龄相关的疾病方面起着关键作用，但它对 DR 发展的影响（直接或间接）仍在很大程度上研究不足。尽管如此，一些研究表明，与衰老相关的退化和 DR 发展有共同的风险因素，这有助于解释为什么在老年人群中 DR 和视力障碍的患病率增加。本综述旨在为衰老和 DR 发展这两个相互交织的病理生理过程提供一些概念上的见解，并讨论在长寿时代 DR 的潜在治疗策略，包括预防和治疗。
