Department of Infectious Diseases, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan; Division of Pharmacodynamics, Keio University Faculty of Pharmacy, Minato-ku, Tokyo, Japan.
Department of Infectious Diseases, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan; Keio University Health Center, Shinjuku-ku, Tokyo, Japan.
J Infect Chemother. 2023 Jun;29(6):628-630. doi: 10.1016/j.jiac.2023.03.004. Epub 2023 Mar 8.
Nontuberculous mycobacteria (NTM) are environmental bacteria resistant to many common disinfectants and ultraviolet radiation. Inhalation of aerosols generated from NTM-containing water and soil causes NTM lung disease, especially in people with underlying lung diseases and decreased immunity. To prevent healthcare-acquired NTM infections, it is important to eradicate NTM living in hospital environments. Therefore, we evaluated the efficacy of gaseous ozone for the inactivation of NTM, namely Mycobacterium (M.) avium, M. intracellulare, M. kansasii, M. abscessus subsp. abscessus and M.abscessus subsp. massiliense. Gaseous ozone treatment at 1 ppm for 3 h reduced the bacterial number of all strains by more than 97%. Gaseous ozone treatment could be a practical, effective and convenient disinfection method for NTM living in hospital environments.
非结核分枝杆菌（NTM）是一种对许多常见消毒剂和紫外线辐射具有抗性的环境细菌。吸入来自含 NTM 的水和土壤产生的气溶胶会导致 NTM 肺部疾病，尤其是在患有基础肺部疾病和免疫力下降的人群中。为了预防医源性 NTM 感染，消除存在于医院环境中的 NTM 至关重要。因此，我们评估了气态臭氧对 NTM（即鸟分枝杆菌、胞内分枝杆菌、堪萨斯分枝杆菌、脓肿分枝杆菌亚种脓肿和脓肿分枝杆菌亚种马萨诸塞）的灭活效果。在 1 ppm 下处理 3 小时，可使所有菌株的细菌数量减少 97%以上。气态臭氧处理可能是一种实用、有效且方便的用于医院环境中 NTM 的消毒方法。
