Mészáros K, Lang C H, Bagby G J, Spitzer J J
Department of Physiology, Louisiana State University Medical Center, New Orleans 70112.
Biochem Biophys Res Commun. 1987 Nov 30;149(1):1-6. doi: 10.1016/0006-291x(87)91596-8.
Glucose utilization of different tissues was investigated in vivo by the 2-deoxyglucose tracer technique. After infusion of a non-lethal dose of recombinant human TNF-alpha (150 micrograms/kg) to rats, glucose utilization was increased by 80-100% in spleen, liver, kidney, by 60% in skin and by 30-40% in lung and ileum. The largest increase (150%) was observed in the diaphragm. There was no significant change in glucose utilization by skeletal muscles, testis and brain. These data show that TNF exerts metabolic effects on macrophage-rich tissues, and suggest that enhanced secretion of TNF may be one of the important factors in eliciting the metabolic changes in sepsis and endotoxicosis.
采用2-脱氧葡萄糖示踪技术在体内研究了不同组织的葡萄糖利用情况。给大鼠输注非致死剂量的重组人肿瘤坏死因子-α（150微克/千克）后，脾脏、肝脏、肾脏的葡萄糖利用增加了80%-100%，皮肤增加了60%，肺和回肠增加了30%-40%。在膈肌中观察到最大增幅（150%）。骨骼肌、睾丸和大脑的葡萄糖利用没有显著变化。这些数据表明肿瘤坏死因子对富含巨噬细胞的组织发挥代谢作用，并提示肿瘤坏死因子分泌增加可能是引发脓毒症和内毒素血症代谢变化的重要因素之一。
