Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin, China.
Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio.
Biol Psychiatry. 2023 Jun 15;93(12):1071-1080. doi: 10.1016/j.biopsych.2023.01.005. Epub 2023 Jan 16.
The dentate gyrus, a "gate" that controls the flow of information into the hippocampus, is critical for learning, memory, spatial navigation, and mood regulation. Several lines of evidence have demonstrated that deficits in dentate granule cells (DGCs) (e.g., loss of DGCs or genetic mutations in DGCs) contribute to the development of various psychiatric disorders, such as depression and anxiety disorders. Whereas ventral DGCs are believed to be critical for mood regulation, the functions of dorsal DGCs in this regard remain elusive. Here, we review the role of DGCs, in particular the dorsal DGCs, in the regulation of mood, their functional relationships with DGC development, and the contributions of dysfunctional DGCs to mental disorders.
齿状回是控制信息流入海马体的“门”，对于学习、记忆、空间导航和情绪调节至关重要。有几条证据表明，颗粒细胞（DGCs）的缺陷（例如，DGCs 的丧失或 DGCs 中的基因突变）导致了各种精神疾病的发展，如抑郁症和焦虑症。虽然腹侧 DGCs 被认为对情绪调节至关重要，但背侧 DGCs 在这方面的功能仍然难以捉摸。在这里，我们回顾了 DGCs，特别是背侧 DGCs，在调节情绪方面的作用，它们与 DGC 发育的功能关系，以及功能失调的 DGCs 对精神障碍的贡献。
