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Transglutaminase 2 and Ferroptosis: a new liaison?

作者信息

Gagliardi Mara, Saverio Valentina, Rossin Federica, D'Eletto Manuela, Corazzari Marco

机构信息

Department of Health Sciences and Center for Translational Research on Autoimmune and Allergic Disease (CAAD), University of Piemonte Orientale, Novara, IT, Italy.

Department of Biology, University of Rome Tor Vergata, Rome, IT, Italy.

出版信息

Cell Death Discov. 2023 Mar 9;9(1):88. doi: 10.1038/s41420-023-01394-1.

DOI:10.1038/s41420-023-01394-1
PMID:36894531
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9998634/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4fe/9998634/957b8704b82b/41420_2023_1394_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4fe/9998634/957b8704b82b/41420_2023_1394_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4fe/9998634/957b8704b82b/41420_2023_1394_Fig1_HTML.jpg

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The CXCR3/PLC/IP3-IP3R axis is responsible for the ignition of UPR in intestinal epithelial cells exposed to gliadin peptide, during the onset of celiac disease.在乳糜泻发病期间，CXCR3/PLC/IP3-IP3R轴负责在暴露于麦醇溶蛋白肽的肠上皮细胞中引发未折叠蛋白反应。
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本文引用的文献

1
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications.铁死亡研究十周年：新兴机制、生理功能与治疗应用
Cell. 2022 Jul 7;185(14):2401-2421. doi: 10.1016/j.cell.2022.06.003.
2
NCOA4-mediated ferritinophagy promotes ferroptosis induced by erastin, but not by RSL3 in HeLa cells.NCOA4 介导的铁蛋白自噬促进依马替尼诱导的铁死亡，但不促进 RSL3 诱导的铁死亡。
Biochim Biophys Acta Mol Cell Res. 2021 Feb;1868(2):118913. doi: 10.1016/j.bbamcr.2020.118913. Epub 2020 Nov 25.
3
Ferroptosis: a new unexpected chance to treat metastatic melanoma?
AKRs confer oligodendrocytes resistance to differentiation-stimulated ferroptosis.醛酮还原酶赋予少突胶质细胞对分化刺激引起的铁死亡的抗性。
Redox Biol. 2025 Feb;79:103463. doi: 10.1016/j.redox.2024.103463. Epub 2024 Dec 9.
4
The Role of Ferroptosis in Amyotrophic Lateral Sclerosis Treatment.铁死亡在肌萎缩侧索硬化症治疗中的作用。
Neurochem Res. 2024 Oct;49(10):2653-2667. doi: 10.1007/s11064-024-04194-w. Epub 2024 Jun 12.
5
Ferroptosis inhibitors: past, present and future.铁死亡抑制剂：过去、现在与未来
Front Pharmacol. 2024 May 23;15:1407335. doi: 10.3389/fphar.2024.1407335. eCollection 2024.
6
The Role of Transglutaminase 2 in Cancer: An Update.转谷氨酰胺酶2在癌症中的作用：最新进展
Int J Mol Sci. 2024 Feb 28;25(5):2797. doi: 10.3390/ijms25052797.
7
FSP1 is a predictive biomarker of osteosarcoma cells' susceptibility to ferroptotic cell death and a potential therapeutic target.FSP1是骨肉瘤细胞对铁死亡性细胞死亡敏感性的预测生物标志物及潜在治疗靶点。
Cell Death Discov. 2024 Feb 17;10(1):87. doi: 10.1038/s41420-024-01854-2.
铁死亡：治疗转移性黑色素瘤的新契机？
Cell Cycle. 2020 Oct;19(19):2411-2425. doi: 10.1080/15384101.2020.1806426. Epub 2020 Aug 20.
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GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling.鸟苷三磷酸环化水解酶1/四氢生物蝶呤通过脂质重塑对抗铁死亡。
ACS Cent Sci. 2020 Jan 22;6(1):41-53. doi: 10.1021/acscentsci.9b01063. Epub 2019 Dec 27.
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Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.醛酮还原酶保护转移性黑色素瘤免受内质网应激非依赖性铁死亡。
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FSP1 is a glutathione-independent ferroptosis suppressor.FSP1 是一种谷胱甘肽不依赖的铁死亡抑制因子。
Nature. 2019 Nov;575(7784):693-698. doi: 10.1038/s41586-019-1707-0. Epub 2019 Oct 21.
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Cell. 2018 Jan 25;172(3):409-422.e21. doi: 10.1016/j.cell.2017.11.048. Epub 2017 Dec 28.
8
Ferroptosis: an iron-dependent form of nonapoptotic cell death.铁死亡：一种依赖于铁的非细胞凋亡性细胞死亡形式。
Cell. 2012 May 25;149(5):1060-72. doi: 10.1016/j.cell.2012.03.042.
9
TG2 transamidating activity acts as a reostat controlling the interplay between apoptosis and autophagy.TG2 的转酰胺化活性起到变阻器的作用，控制着细胞凋亡和自噬之间的相互作用。
Amino Acids. 2012 May;42(5):1793-802. doi: 10.1007/s00726-011-0899-x. Epub 2011 Apr 10.