GTS Research Group, Department of Chemistry, Faculty of Science, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.
Mikrochim Acta. 2023 Mar 9;190(4):125. doi: 10.1007/s00604-023-05692-4.
Olivetol (OLV), as a cannabidiol (CBD) analog, was incorporated in γ-cyclodextrin metal-organic frameworks (γ-CD-MOFs) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes as potential analgesic drug delivery systems (DDS) for dental hypersensitivity (DH) treatment. These DDS have been scarcely employed in oral health, being the first time in case of MOFs loaded with cannabinoids. In vitro experiments using bovine teeth were performed to verify if the drug is able to reach the dentin, where it can flow to the pulp tissues and exert its analgesic effect; enamel and dentin regions were analyzed by synchrotron radiation-based FTIR microspectroscopy. Principal component analysis (PCA) was used to process the spectroscopic data as a powerful chemometric tool, and it revealed a similar behavior in both regions. The studied DDS have been characterized by different techniques, and is was demonstrated that DDS is an efficient way to carry the drug through dental tissues without compromising their structure.
橄榄醇（OLV）作为一种大麻二酚（CBD）类似物，被掺入 γ-环糊精金属有机骨架（γ-CD-MOFs）和 1,2-二月桂酰基-sn-甘油-3-磷酸胆碱（DPPC）脂质体中，作为治疗牙本质敏感症（DH）的潜在镇痛药物传递系统（DDS）。这些 DDS 在口腔健康中很少被使用，而在负载大麻素的 MOFs 中则是首次使用。使用牛牙进行了体外实验，以验证药物是否能够到达牙本质，在那里它可以流向牙髓组织并发挥其镇痛作用；使用基于同步辐射的傅里叶变换红外显微镜光谱法分析了釉质和牙本质区域。主成分分析（PCA）被用作一种强大的化学计量工具来处理光谱数据，结果表明在这两个区域都有类似的行为。通过不同的技术对研究中的 DDS 进行了表征，证明 DDS 是一种通过牙齿组织输送药物而不损害其结构的有效方法。
