Majdinasab Nastaran, Orakifar Neda, Kouti Leila, Shamsaei Gholamreza, Seyedtabib Maryam, Jafari Mohammad
Member of Musculoskeletal Rehabilitation Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Physiotherapy, School of Rehabilitation Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Front Neurosci. 2023 Feb 21;17:1107886. doi: 10.3389/fnins.2023.1107886. eCollection 2023.
Overactive bladder (OAB) is one of the most common complications in patients with multiple sclerosis (MS). Choosing the effective treatment is very important in improving their quality of life (QOL). Therefore, the aim of this study was to compare solifenacin (SS) and posterior tibial nerve stimulation (PTNS) treatment effects in the MS Patients with OAB.
In total, 70 MS patients suffering from OAB enrolled in this clinical trial study. Patients with a score of at least 3 according to the OAB questionnaire were randomly divided into two groups (35 patients in each group). In one group, patients received SS (5 mg daily for 4 weeks and 10 mg/day for another 8 weeks) and in a second group, patients were treated by PTNS (12 weekly session, 30 min).
The mean (SD) age of patients participating in this study was 39.82 (9.088) and 42.41 (9.175) years for the SS group and the PTNS group, respectively. Patients in both groups showed statistically significant improvements in urinary incontinence, micturition, and daytime frequency ( < 0.001). Patients in the SS group had a better response for urinary incontinence after 12 weeks compared to the PTNS group. Also, patients in the SS group reported higher satisfaction and less daytime frequency compared to the PTNS group.
SS and PTNS were effective for improving the OAB symptoms in patients with MS. However, patients demonstrated a better experience with SS in terms of daytime frequency, urinary incontinence, and treatment satisfaction rate.
膀胱过度活动症（OAB）是多发性硬化症（MS）患者最常见的并发症之一。选择有效的治疗方法对改善他们的生活质量（QOL）非常重要。因此，本研究的目的是比较索利那新（SS）和胫后神经刺激（PTNS）对MS合并OAB患者的治疗效果。
共有70例患有OAB的MS患者参与了这项临床试验研究。根据OAB问卷评分至少为3分的患者被随机分为两组（每组35例）。一组患者接受SS治疗（前4周每天5mg，后8周每天10mg），另一组患者接受PTNS治疗（每周12次，每次30分钟）。
参与本研究的患者的平均（标准差）年龄，SS组为39.82（9.088）岁，PTNS组为42.41（9.175）岁。两组患者在尿失禁、排尿和日间排尿频率方面均有统计学意义的改善（<0.001）。与PTNS组相比，SS组患者在12周后对尿失禁的反应更好。此外，与PTNS组相比，SS组患者报告的满意度更高，日间排尿频率更低。
SS和PTNS对改善MS患者的OAB症状均有效。然而，在日间排尿频率、尿失禁和治疗满意率方面，患者使用SS的体验更好。
