Bampidis Vasileios, Azimonti Giovanna, Bastos Maria de Lourdes, Christensen Henrik, Dusemund Birgit, Fašmon Durjava Mojca, Kouba Maryline, López-Alonso Marta, López Puente Secundino, Marcon Francesca, Mayo Baltasar, Pechová Alena, Petkova Mariana, Ramos Fernando, Sanz Yolanda, Villa Roberto Edoardo, Woutersen Ruud, Anguita Montserrat, Brozzi Rosella, Innocenti Matteo, Ortuño Jordi, García-Cazorla Yolanda
EFSA J. 2023 Mar 7;21(3):e07871. doi: 10.2903/j.efsa.2023.7871. eCollection 2023 Mar.
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the efficacy of the preparation consisting of viable cells of CNCM I-4606, CNCM I-5043, CNCM I-4607 and CNCM I-4609 when used as a technological additive (hygiene condition enhancer) for all animal species. In a previous opinion, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concluded that the additive is safe for the target species, consumers and the environment. The Panel also considered the additive to be non-irritant to skin and eyes, nor a dermal sensitiser, but a respiratory sensitiser. Moreover, the data provided were not sufficient to conclude on the efficacy of the additive to significantly reduce the growth of Typhimurium or in feed. In the current assessment, the applicant provided supplementary information to address these flaws and limited the claimed effect to 'prevent (re)contamination by Typhimurium'. Based on the new studies, the Panel concluded that the additive at a minimum proposed inclusion level of 1 × 10 colony forming units (CFU) and 1 × 10 CFU per litre showed potential to reduce Typhimurium growth in feeds with high moisture content (60-90% moisture).
应欧盟委员会的要求，欧洲食品安全局（EFSA）被要求就由法国国家微生物保藏中心（CNCM）的I-4606、I-5043、I-4607和I-4609号活细胞组成的制剂用作所有动物物种的技术添加剂（卫生条件增强剂）的功效发表科学意见。在先前的一份意见中，动物饲料添加剂和产品或物质专家小组（FEEDAP）得出结论，该添加剂对目标物种、消费者和环境是安全的。该专家小组还认为该添加剂对皮肤和眼睛无刺激性，也不是皮肤致敏剂，但却是呼吸道致敏剂。此外，所提供的数据不足以得出该添加剂能显著减少饲料中鼠伤寒沙门氏菌生长的结论。在本次评估中，申请人提供了补充信息以弥补这些缺陷，并将声称的效果限定为“防止鼠伤寒沙门氏菌再次污染”。基于这些新的研究，专家小组得出结论，该添加剂在每升最低建议添加量1×10菌落形成单位（CFU）和1×10 CFU时，显示出有潜力减少高水分含量（60 - 90%水分）饲料中鼠伤寒沙门氏菌的生长。
