Bampidis Vasileios, Azimonti Giovanna, Bastos Maria de Lourdes, Christensen Henrik, Dusemund Birgit, Durjava Mojca Fašmon, Kouba Maryline, López-Alonso Marta, López Puente Secundino, Marcon Francesca, Mayo Baltasar, Pechová Alena, Petkova Mariana, Ramos Fernando, Sanz Yolanda, Villa Roberto Edoardo, Woutersen Ruud, Saarela Maria, Anguita Montserrat, Cazorla Yolanda García, Galobart Jaume, Innocenti Matteo, Pettenati Elisa, Tarrés Jordi, Revez Joana, Brozzi Rosella
EFSA J. 2022 Aug 10;20(8):e07424. doi: 10.2903/j.efsa.2022.7424. eCollection 2022 Aug.
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of CNCM I-4622 when used as a technological additive (acidity regulator and hygiene condition enhancers) for all animal species. The product is intended for use in mash compound feeds and/or solid feed materials used for the preparation of liquid feeds at a minimum inclusion level of 1 × 10 CFU kg feed. The bacterial species is considered by EFSA to be eligible for the qualified presumption of safety (QPS) approach. As the identity of the strain has been clearly established and it did not show acquired resistance to antibiotics of human and veterinary importance, the use of this strain in animal nutrition is considered safe for the target species, consumers and the environment. The additive is considered to be a respiratory sensitiser but is not irritant to eyes/skin or a skin sensitiser. CNCM I-4622 at 1 × 10 CFU/kg complete feed showed the potential to reduce the pH and the growth of coliforms in liquid feeds. CNCM I-4622 is compatible with halofuginone, diclazuril, decoquinate and nicarbazin at the highest authorised levels for chickens for fattening.
应欧盟委员会的要求，动物饲料添加剂及产品或物质专家小组（FEEDAP）被要求就CNCM I-4622用作所有动物物种的技术添加剂（酸度调节剂和卫生条件增强剂）时的安全性和有效性发表科学意见。该产品旨在用于预混料复合饲料和/或用于制备液体饲料的固体饲料原料，最低添加水平为每千克饲料1×10 CFU。欧洲食品安全局（EFSA）认为该细菌物种符合安全合格假定（QPS）方法的条件。由于该菌株的身份已明确确定，且未表现出对人类和兽医重要抗生素的获得性耐药性，因此在动物营养中使用该菌株对目标物种、消费者和环境被认为是安全的。该添加剂被认为是一种呼吸道致敏原，但对眼睛/皮肤无刺激性，也不是皮肤致敏原。每千克全价饲料中添加1×10 CFU的CNCM I-4622显示出降低液体饲料pH值和减少大肠菌群生长的潜力。CNCM I-4622与育肥鸡最高授权水平的常山酮、地克珠利、癸氧喹酯和尼卡巴嗪兼容。
