Bampidis Vasileios, Azimonti Giovanna, Bastos Maria de Lourdes, Christensen Henrik, Dusemund Birgit, Fašmon Durjava Mojca, Kouba Maryline, López-Alonso Marta, López Puente Secundino, Marcon Francesca, Mayo Baltasar, Pechová Alena, Petkova Mariana, Ramos Fernando, Sanz Yolanda, Villa Roberto Edoardo, Woutersen Ruud, Saarela Maria, Galobart Jaume, Innocenti Matteo, Revez Joana, Vettori Maria Vittoria, Brozzi Rosella
EFSA J. 2021 Nov 19;19(11):e06907. doi: 10.2903/j.efsa.2021.6907. eCollection 2021 Nov.
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the preparation of CNCM I-4606, CNCM I-5043, CNCM I-4607 and CNCM I-4609 when used as a technological additive (hygiene condition enhancer) for all animal species. The product is intended for use in compound feeds and feed materials for all animal species at a minimum inclusion level of 1 × 10 CFU and 1 × 10 CFU per kg or litre. The two bacterial species are considered by EFSA to be eligible for the qualified presumption of safety (QPS) approach. As the identity of the strains has been clearly established and they did not show acquired resistance to antibiotics of human and veterinary importance, the use of these strains in animal nutrition is considered safe for the target species, consumers and the environment. The additive is not irritant to skin and eyes or a skin sensitiser. Given the proteinaceous nature of the active agents, the additive should be considered a respiratory sensitiser. The Panel is not in the position to conclude on the efficacy of the additive to significantly reduce the growth of either Typhimurium or in feed.
应欧盟委员会的要求，动物饲料添加剂及产品或物质专家小组（FEEDAP）被要求就CNCM I - 4606、CNCM I - 5043、CNCM I - 4607和CNCM I - 4609用作所有动物物种的技术添加剂（卫生条件增强剂）时的制剂提供科学意见。该产品拟用于所有动物物种的配合饲料和饲料原料，最低添加水平为每千克或每升1×10 CFU和1×10 CFU。欧洲食品安全局（EFSA）认为这两种细菌符合安全合格假定（QPS）方法的条件。由于菌株的身份已明确确定，且它们未表现出对人类和兽医重要抗生素的获得性耐药性，因此在动物营养中使用这些菌株被认为对目标物种、消费者和环境是安全的。该添加剂对皮肤和眼睛无刺激性，也不是皮肤致敏剂。鉴于活性剂的蛋白质性质，该添加剂应被视为呼吸道致敏剂。专家小组无法就该添加剂显著减少饲料中鼠伤寒沙门氏菌或其他菌生长的功效得出结论。
