Ragnarsson B, Raabe N, Willems J, Pettersson F
Department of Gynaecological Oncology, Radiumhemmet, Stockholm, Sweden.
Acta Oncol. 1987;26(4):277-80. doi: 10.3109/02841868709089975.
Seventy-four patients with carcinoma in situ (CIS) of the vulva were followed over a 10-year period. The mean age was 52.8 years (range 21 to 90 years). Pruritus was the most common symptom. Forty per cent of the women were asymptomatic. Twenty-three per cent had a history of carcinoma in situ of the uterine cervix. Single lesions of CIS were found in the perineal area in 22 per cent, in the labia major and minor in 23 per cent, and in the clitoris in 7 per cent. Forty-two per cent of the patients had CIS in two or more of those areas. Seven of 74 patients (10%) had previously been irradiated for pelvic malignant tumours. Three women developed invasive squamous cell carcinoma of the vulva, two of them were previously irradiated. All 74 patients were treated surgically in different ways. Out of 38 women with histologically free margins of surgery, 6 had recurrence of dysplasia or CIS.
74例患有外阴原位癌（CIS）的患者接受了为期10年的随访。平均年龄为52.8岁（范围21至90岁）。瘙痒是最常见的症状。40%的女性无症状。23%的患者有子宫颈原位癌病史。22%的患者会阴区发现单个CIS病变，23%的患者大、小阴唇发现病变，7%的患者阴蒂发现病变。42%的患者在两个或更多这些区域患有CIS。74例患者中有7例（10%）先前因盆腔恶性肿瘤接受过放疗。3名女性发生了外阴浸润性鳞状细胞癌，其中2名先前接受过放疗。所有74例患者均接受了不同方式的手术治疗。在38例手术切缘组织学检查阴性的女性中，6例出现发育异常或CIS复发。
