Buscema J, Woodruff J D, Parmley T H, Genadry R
Obstet Gynecol. 1980 Feb;55(2):225-30.
Of 106 patients with carcinoma in situ (CIS) of the vulva, 102 have been followed from 1 to 15 years. The average age of the patient was 47 years; however, 40% were under the age of 41. Twenty-seven percent had associated cervical malignancy. Only 4 patients developed invasive cancer. Of these, 2 were postmenopausal and the 2 younger patients had been immunosuppressed because of systemic disease; thus the subsequent invasive cancer. The incidence of recurrence was essentially the same whether the patient was treated by vulvectomy or wide local excision. In view of the uncertainties about the invasive potential of CIS of the vulva in young patients and the absence of a proved need for an extensive procedure, it is suggested that this entity be treated only by local excision.
106例外阴原位癌患者中，102例已随访1至15年。患者的平均年龄为47岁；然而，40%的患者年龄在41岁以下。27%的患者伴有宫颈恶性肿瘤。只有4例患者发展为浸润性癌。其中，2例为绝经后患者，2例较年轻的患者因全身性疾病而免疫抑制，从而发生了随后的浸润性癌。无论患者接受外阴切除术还是广泛局部切除术，复发率基本相同。鉴于年轻患者外阴原位癌浸润潜能的不确定性，以及缺乏对广泛手术的明确需求，建议仅通过局部切除术治疗该疾病。
