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估算美国和印度 COVID-19 的时变有效繁殖数和疫苗接种率。

Estimating the time-dependent effective reproduction number and vaccination rate for COVID-19 in the USA and India.

机构信息

Department of Mathematics, Central University of Rajasthan, Bandar Sindri, Kishangarh-305817, Ajmer, Rajasthan, India.

Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton AB T6G 2G1, Canada.

出版信息

Math Biosci Eng. 2023 Jan;20(3):4673-4689. doi: 10.3934/mbe.2023216. Epub 2022 Dec 28.

Abstract

The effective reproduction number, $ R_t $, is a vital epidemic parameter utilized to judge whether an epidemic is shrinking, growing, or holding steady. The main goal of this paper is to estimate the combined $ R_t $ and time-dependent vaccination rate for COVID-19 in the USA and India after the vaccination campaign started. Accounting for the impact of vaccination into a discrete-time stochastic augmented SVEIR (Susceptible-Vaccinated-Exposed-Infectious-Recovered) model, we estimate the time-dependent effective reproduction number $ (R_t) $ and vaccination rate $ (\xi_t) $ for COVID-19 by using a low pass filter and the Extended Kalman Filter (EKF) approach for the period February 15, 2021 to August 22, 2022 in India and December 13, 2020 to August 16, 2022 in the USA. The estimated $ R_t $ and $ \xi_t $ show spikes and serrations with the data. Our forecasting scenario represents the situation by December 31, 2022 that the new daily cases and deaths are decreasing for the USA and India. We also noticed that for the current vaccination rate, $ R_t $ would remain greater than one by December 31, 2022. Our results are beneficial for the policymakers to track the status of the effective reproduction number, whether it is greater or less than one. As restrictions in these countries ease, it is still important to maintain safety and preventive measures.

摘要

有效繁殖数$R_t$是用于判断传染病是在减少、增加还是稳定的重要传染病参数。本文的主要目的是在疫苗接种运动开始后,估计美国和印度 COVID-19 的综合$R_t$和时变疫苗接种率。考虑到疫苗接种对离散时间随机增强 SVEIR(易感-接种-暴露-感染-恢复)模型的影响,我们使用低通滤波器和扩展卡尔曼滤波器(EKF)方法,对 2021 年 2 月 15 日至 2022 年 8 月 22 日期间的印度和 2020 年 12 月 13 日至 2022 年 8 月 16 日的美国 COVID-19 进行了时变有效繁殖数$R_t$和疫苗接种率$\xi_t$的估计。估计的$R_t$和$\xi_t$显示出与数据的尖峰和锯齿。我们的预测情景代表了到 2022 年 12 月 31 日,美国和印度的新的每日病例和死亡人数呈下降趋势的情况。我们还注意到,对于当前的疫苗接种率,到 2022 年 12 月 31 日,$R_t$仍将大于 1。我们的结果有助于政策制定者跟踪有效繁殖数的状况,判断其是否大于或小于 1。随着这些国家的限制放宽,保持安全和预防措施仍然很重要。

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