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纳入可能病例的隔室流行模型以模拟检测能力有限地区的 COVID-19 疫情。

A compartmental epidemic model incorporating probable cases to model COVID-19 outbreak in regions with limited testing capacity.

机构信息

Mærsk McKinney Møller Institute, University of Southern Denmark, Denmark.

Department of Mathematics, University of Mulawarman, Indonesia.

出版信息

ISA Trans. 2022 May;124:157-163. doi: 10.1016/j.isatra.2021.01.029. Epub 2021 Jan 20.

Abstract

We propose a new compartmental epidemic model taking into account people who have symptoms with no confirmatory laboratory testing (probable cases). We prove well-posedness of the model and provide an explicit expression for the basic reproduction number (R). We use the model together with an extended Kalman filter (EKF) to estimate the time-varying effective reproduction number (R) of COVID-19 in West Java province in Indonesia and the state of Michigan in the USA, where laboratory testing capacities are limited. Based on our estimation, the value of R is higher when the probable cases are taken into account. This correction can be used by decision and policy makers when considering re-opening policy and evaluation of public measures.

摘要

我们提出了一个新的隔室传染病模型,考虑了那些有症状但未经确证性实验室检测的人(可能病例)。我们证明了模型的适定性,并给出了基本繁殖数(R)的显式表达式。我们使用该模型和扩展卡尔曼滤波器(EKF)来估计印度尼西亚西爪哇省和美国密歇根州的 COVID-19 时变有效繁殖数(R),这两个地区的实验室检测能力有限。根据我们的估计,当考虑可能病例时,R 的值更高。决策者在考虑重新开放政策和评估公共措施时,可以使用这一修正。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/855b/7817488/03d81404364a/gr1_lrg.jpg

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