Cramér K, Dahlberg L
Br J Ind Med. 1966 Apr;23(2):101-4. doi: 10.1136/oem.23.2.101.
Three hundred and sixty-four workers employed in an accumulator factory had at least three bloodpressure determinations during 1962 in a study of the relation between lead exposure and the incidence of hypertension. In this group 46 workers were found to have hypertension; the expected incidence was 51. Two hundred and seventy-three of the total group, all over 35 years, had been employed for a sufficiently long time to be considered as having had a long-term exposure to lead. On the basis of urinary coproporphyrin tests, they were divided into a lead-affected' group (141) and a non-lead-affected' group (132). There were 22 persons with hypertension in the former group, and 20 in the latter. There was no significant difference in the appearance of hypertension in these two groups either from the standpoint of age or from the duration of exposure to lead. Two hundred and sixty-five workers had been employed at the factory for 10 or more years, and 82 of these for more than 20 years. There was a positive correlation between the incidence of hypertension and the duration of employment, but no difference between the lead-affected' and non-lead-affected' groups. This observation is understandable in view of the increasing incidence of hypertension with advancing age. The study shows that workers in an accumulator factory, in which the working conditions are inspected and controlled regularly and in which the workers themselves are examined regularly for the influence of lead, are not more prone to hypertension than the general population. In view of the possibility of vascular damage after exposure to lead, blood pressures in lead-workers should be watched, and treatment started early if hypertension is found.
1962年,在一项关于铅暴露与高血压发病率关系的研究中,一家蓄电池厂的364名工人至少进行了三次血压测定。在这组工人中,发现46人患有高血压;预期发病率为51人。该组中273名年龄均超过35岁的工人,工作时间足够长,可被视为长期接触铅。根据尿中粪卟啉试验,他们被分为“受铅影响”组(141人)和“未受铅影响”组(132人)。前一组中有22人患有高血压,后一组中有20人患有高血压。从年龄或铅暴露持续时间的角度来看,这两组中高血压的出现没有显著差异。265名工人在该厂工作了10年或更长时间,其中82人工作了20年以上。高血压发病率与工作年限呈正相关,但“受铅影响”组和“未受铅影响”组之间没有差异。鉴于高血压发病率随年龄增长而增加,这一观察结果是可以理解的。该研究表明,在一家工作条件定期接受检查和控制、工人自身也定期接受铅影响检查的蓄电池厂中,工人患高血压的倾向并不比一般人群更高。鉴于接触铅后可能出现血管损伤,应密切关注铅作业工人的血压,如果发现高血压应尽早开始治疗。