Translational Biobehavioral and Health Disparities Branch, National Institutes of Health Clinical Center, Bethesda, Maryland, USA
Translational Biobehavioral and Health Disparities Branch, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
BMJ Open. 2023 Mar 10;13(3):e066913. doi: 10.1136/bmjopen-2022-066913.
The connection of the microbiome to human health intersects with the physical environment of humans. Each microbiome location can be influenced by environmental conditions that relate to specific geographical locations, which in turn are influenced by social determinants of health such as a neighbourhood. The objective of this scoping review is to explore the current evidence on the relationships between microbiome and neighbourhood to explain microbiome-related health outcomes.
Arksey and O'Malley's literature review framework will be employed throughout the process, as well as Page, 's 2020 Preferred Reporting Items for Systematic Review and Meta-Analysis updated workflow to process search results. The literature search will be completed using PubMed/Medline (NLM), Embase (Elsevier), Web of Science, Core Collection (Clarivate Analytics), Scopus (Elsevier), medRxiv preprint server and Open Science Framework server. The search will be conducted using a list of pre-identified Medical Subject Headings (MeSH) terms relating to neighbourhood, microbiome and individual characteristics. There will be no date or language restrictions used in the search. In order to be included in the study, a piece must include an evaluation of the relationship between microbiome diversity and neighbourhood (including at least one measurement of the neighbourhood and at least one human microbiome site). Excluded from the review will be those works that do not include all of these measures, literature reviews based on secondary sources and postmortem populations with no report of premortem health factors. The review itself will be an iterative process completed by two reviewers, with a third individual identified to break ties. Documents will be undergoing a risk assessment of bias in order for the authors to comment on the quality of the literature in this area. Finally, results will be discussed with identified stakeholders, including individuals connected to neighbourhoods facing structural inequity and experts in the topics of study through a community advisory board, for their feedback and knowledge transfer.
This review does not require ethical approval. Results of this search will be disseminated through peer-reviewed publications. Furthermore, this work is completed in conjunction with a community advisory board so as to ensure dissemination to multiple stakeholders.
微生物组与人类健康的联系与人类的物理环境相交织。每个微生物组位置都可能受到与特定地理位置相关的环境条件的影响，而这些地理位置又受到健康的社会决定因素（如社区）的影响。本范围综述的目的是探讨微生物组与社区之间关系的现有证据，以解释与微生物组相关的健康结果。
整个过程将采用阿斯基和奥马利的文献综述框架，以及 2020 年 Page 对系统评价和荟萃分析更新工作流程的偏好报告，以处理搜索结果。文献检索将使用 PubMed/Medline（NLM）、Embase（Elsevier）、Web of Science、核心合集（Clarivate Analytics）、Scopus（Elsevier）、medRxiv 预印本服务器和开放科学框架服务器完成。搜索将使用与社区、微生物组和个体特征相关的预先确定的医学主题词 (MeSH) 术语列表进行。搜索中不会使用日期或语言限制。为了被纳入研究，一项研究必须包括对微生物组多样性与社区之间关系的评估（包括至少一项对社区的测量和至少一项人类微生物组部位的测量）。本综述将排除那些未包含所有这些措施的研究，基于二次来源的文献综述以及没有报告生前健康因素的死后人群。该综述本身将是一个由两名评审员完成的迭代过程，第三名评审员将被确定以打破僵局。为了让作者对该领域文献的质量发表评论，将对文献进行偏倚风险评估。最后，将与利益相关者（包括面临结构性不平等的社区的个人以及研究主题的专家）通过社区咨询委员会讨论结果，以获取他们的反馈和知识转移。
本综述不需要伦理批准。搜索结果将通过同行评审出版物传播。此外，这项工作是与社区咨询委员会合作完成的，以确保向多个利益相关者传播。
