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利用同伴支持预防糖尿病:一项实用随机对照试验的结果。

Using Peer Support to Prevent Diabetes: Results of a Pragmatic RCT.

机构信息

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan; Institute for Healthcare Policy & Innovation, University of Michigan, Ann Arbor, Michigan; Department of Health Behavior and Health Education, School of Public Health, University of Michigan, Ann Arbor, Michigan; VA Center for Clinical Management Research, VA Ann Arbor Healthcare System, Ann Arbor, Michigan.

Division of Research, Kaiser Permanente Northern California, Oakland, California.

出版信息

Am J Prev Med. 2023 Aug;65(2):239-250. doi: 10.1016/j.amepre.2023.02.015. Epub 2023 Mar 8.

Abstract

INTRODUCTION

High-contact structured diabetes prevention programs are effective in lowering weight and HbA1cs, yet their intensity level can create barriers to participation. Peer support programs improve clinical outcomes among adults with Type 2 diabetes, but their effectiveness in diabetes prevention is unknown. This study examined whether a low-intensity peer support program improved outcomes more than enhanced usual care in a diverse population with prediabetes.

STUDY DESIGN

The intervention was tested in a pragmatic 2-arm RCT.

SETTING/PARTICIPANTS: Participants were adults with prediabetes at three healthcare centers.

INTERVENTION

Participants randomized to the enhanced usual care arm received educational materials. Participants in the Using Peer Support to Aid in Prevention and Treatment in Prediabetes arm were matched with a peer supporter: another patient who had made healthy lifestyle changes and was trained in autonomy-supportive action planning. Peer supporters were instructed to provide weekly telephone support to their peers on specific action steps toward behavioral goals for 6 months, then monthly support for 6 months.

MAIN OUTCOME MEASURES

Changes in primary outcomes of weight and HbA1c and secondary outcomes of enrollment in formal diabetes prevention programs, self-reported diet, physical activity, health-specific social support, self-efficacy, motivation, and activation at 6 and 12 months were examined.

RESULTS

Data collection occurred from October 2018 to March 2022, with analyses completed in September 2022. Among 355 randomized patients, in intention-to-treat analyses, there were no between-group differences in HbA1c or weight changes at 6 and 12 months. Using Peer Support to Aid in Prevention and Treatment in Prediabetes participants were more likely to enroll in structured programs at 6 (AOR=2.45, p=0.009) and 12 (AOR=2.21, p=0.016) months and to report eating whole grains at 6 (4.49, p=0.026) and 12 (4.22, p=0.034) months. They reported greater improvements in perceived social support for diabetes prevention behaviors at 6 (6.39, p<0.001) and 12 (5.48, p<0.001) months, with no differences in other measures.

CONCLUSIONS

A stand-alone, low-intensity peer support program improved social support and participation in formal diabetes prevention programs but not weight or HbA1c. It will be important to examine whether peer support could effectively complement higher-intensity, structured diabetes prevention programs.

TRIAL REGISTRATION

This trial is registered at ClinicalTrials.gov, NCT03689530. Full protocol available at https://clinicaltrials.gov/ct2/show/NCT03689530.

摘要

简介

高接触结构化的糖尿病预防计划在降低体重和糖化血红蛋白方面非常有效,但它们的强度水平可能会成为参与的障碍。同伴支持计划可以改善 2 型糖尿病患者的临床结局,但它们在糖尿病预防方面的有效性尚不清楚。本研究旨在探讨在具有不同特征的前驱糖尿病患者中,低强度同伴支持计划是否比强化常规护理更能改善结局。

研究设计

该干预措施在一项实用的 2 臂 RCT 中进行了测试。

设置/参与者:参与者为三家医疗中心的前驱糖尿病患者。

干预措施

接受强化常规护理组的参与者接受教育材料。使用同伴支持辅助预防和治疗前驱糖尿病组的参与者与同伴支持者相匹配:另一位患者已经做出了健康的生活方式改变,并接受了自主支持行动计划的培训。同伴支持者被指示在 6 个月内每周通过电话向他们的同伴提供针对行为目标的具体行动步骤的支持,然后在接下来的 6 个月内每月提供支持。

主要观察指标

6 个月和 12 个月时体重和糖化血红蛋白的主要结局以及正式糖尿病预防计划的参与情况、自我报告的饮食、身体活动、特定于健康的社会支持、自我效能感、动机和激活的次要结局的变化情况。

结果

数据收集于 2018 年 10 月至 2022 年 3 月进行,分析于 2022 年 9 月完成。在 355 名随机患者中,意向治疗分析显示,6 个月和 12 个月时两组的糖化血红蛋白或体重变化无差异。使用同伴支持辅助预防和治疗前驱糖尿病组的患者更有可能在 6 个月(AOR=2.45,p=0.009)和 12 个月(AOR=2.21,p=0.016)时参加结构化计划,并且在 6 个月(4.49,p=0.026)和 12 个月(4.22,p=0.034)时报告食用全麦食品。他们报告在 6 个月(6.39,p<0.001)和 12 个月(5.48,p<0.001)时对预防糖尿病行为的感知社会支持有更大的改善,而其他措施没有差异。

结论

一项独立的、低强度的同伴支持计划可以改善社会支持和参与正式的糖尿病预防计划,但不能改善体重或糖化血红蛋白。重要的是要研究同伴支持是否可以有效地补充更高强度的结构化糖尿病预防计划。

试验注册

本试验在 ClinicalTrials.gov 注册,NCT03689530。完整的方案可在 https://clinicaltrials.gov/ct2/show/NCT03689530 上获取。

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