使用可穿戴式激光多普勒血流仪评估新冠病毒感染后血液微循环变化
Assessment of Blood Microcirculation Changes after COVID-19 Using Wearable Laser Doppler Flowmetry.
作者信息
Zharkikh Elena V, Loktionova Yulia I, Fedorovich Andrey A, Gorshkov Alexander Y, Dunaev Andrey V
机构信息
Research and Development Center of Biomedical Photonics, Orel State University, Komsomolskaya 95, Orel 302026, Russia.
National Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of the Russian Federation, Petroverigsky 10, Moscow 101990, Russia.
出版信息
Diagnostics (Basel). 2023 Mar 1;13(5):920. doi: 10.3390/diagnostics13050920.
The present work is focused on the study of changes in microcirculation parameters in patients who have undergone COVID-19 by means of wearable laser Doppler flowmetry (LDF) devices. The microcirculatory system is known to play a key role in the pathogenesis of COVID-19, and its disorders manifest themselves long after the patient has recovered. In the present work, microcirculatory changes were studied in dynamics on one patient for 10 days before his disease and 26 days after his recovery, and data from the group of patients undergoing rehabilitation after COVID-19 were compared with the data from a control group. A system consisting of several wearable laser Doppler flowmetry analysers was used for the studies. The patients were found to have reduced cutaneous perfusion and changes in the amplitude-frequency pattern of the LDF signal. The obtained data confirm that microcirculatory bed dysfunction is present in patients for a long period after the recovery from COVID-19.
本研究聚焦于通过可穿戴激光多普勒血流仪（LDF）设备，对感染新型冠状病毒肺炎（COVID-19）患者的微循环参数变化进行研究。已知微循环系统在COVID-19发病机制中起关键作用，且其紊乱在患者康复后很长时间仍会显现。在本研究中，对一名患者在患病前10天及康复后26天的微循环变化进行了动态研究，并将COVID-19康复后接受康复治疗的患者组数据与对照组数据进行了比较。研究使用了由多个可穿戴激光多普勒血流仪分析仪组成的系统。结果发现，患者的皮肤灌注减少，且LDF信号的振幅-频率模式发生了变化。所获数据证实，COVID-19康复后的患者在很长一段时间内存在微循环床功能障碍。
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