Papatsimpas Vasileios, Vrouva Sotiria, Papadopoulou Marianna, Papathanasiou George, Bakalidou Daphne
Physiotherapy Department, School of Health and Care Sciences, University of West Attica (UNIWA), 12243 Athens, Greece.
Laboratory of Neuromuscular and Cardiovascular Study of Motion (LANECASM), School of Health and Care Sciences, University of West Attica (UNIWA), 12243 Athens, Greece.
Healthcare (Basel). 2023 Feb 25;11(5):677. doi: 10.3390/healthcare11050677.
Dementia causes deterioration in cognitive and physical functions. The scope of this study is to investigate the effect of different exercise programs on cognitive functions and functionality of persons suffering from mild Alzheimer's disease (AD) by generating information on the exercise types and their parameters. A randomized controlled trial (RCT) will be performed involving aerobic and resistance exercise interventions, taking place both at the sample collection center and at home. Participants will be randomly divided into two different intervention groups and a control group. All groups will be assessed twice; once at baseline and once after 12 weeks. The primary outcome shall comprise the effect of exercise programs on cognitive functions using cognitive testing, such as Addenbrooke's Cognitive Examination-Revisited (ACE-R), Mini Mental State Examination (MMSE), Trail Making Test A-Β (TMT A-B), and Digit Span Test (DST): Digit Span Forward (DSF) and Digit Span Backward (DSB). The effect on functionality will be assessed using the Senior Fitness Test (SFT), Berg Balance Scale (BBS), and Instrumental Activities of Daily Living Scale (IADL) questionnaire. Secondary outcomes include the effect of exercise on depression using the Geriatric Depression Scale-15 (GDS-15), on physical activity using the International Physical Activity Questionnaire (IPAQ), as well as the participants' compliance with the intervention. This study will investigate the possible effect of intervention of different exercise types and the comparison between them. Exercise forms a low-cost and reduced-risk intervention.
痴呆症会导致认知和身体功能衰退。本研究的范围是通过收集有关运动类型及其参数的信息，调查不同运动方案对轻度阿尔茨海默病（AD）患者认知功能和功能状态的影响。将进行一项随机对照试验（RCT），包括有氧运动和抗阻运动干预，干预在样本采集中心和家中进行。参与者将被随机分为两个不同的干预组和一个对照组。所有组将进行两次评估，一次在基线时，一次在12周后。主要结果应包括使用认知测试评估运动方案对认知功能的影响，如修订版Addenbrooke认知检查（ACE-R）、简易精神状态检查表（MMSE）、连线测验A-B（TMT A-B）和数字广度测试（DST）：顺背数字广度（DSF）和倒背数字广度（DSB）。将使用老年人健身测试（SFT）、伯格平衡量表（BBS）和日常生活活动能力量表（IADL）问卷评估对功能状态的影响。次要结果包括使用老年抑郁量表15项版（GDS-15）评估运动对抑郁的影响、使用国际体力活动问卷（IPAQ）评估对体力活动的影响，以及参与者对干预的依从性。本研究将调查不同运动类型干预的可能效果及其之间的比较。运动是一种低成本、低风险的干预措施。
