Haeger Alexa, Costa Ana S, Romanzetti Sandro, Kilders Axel, Trautwein Christian, Haberl Luisa, Beulertz Michael, Hildebrand Frank, Schulz Jörg B, Reetz Kathrin
Department of Neurology RWTH Aachen University Aachen Germany.
JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging Forschungszentrum Jülich GmbH and RWTH Aachen University Aachen Germany.
Alzheimers Dement (N Y). 2020 May 22;6(1):e12032. doi: 10.1002/trc2.12032. eCollection 2020.
Physical activity has shown a positive impact on aging and neurodegeneration and represents a possible treatment option in cognitive decline. However, its underlying mechanisms and influences on brain pathology remain unclear. Dementia-MOVE (Multi-Objective Validation of Exercise) is a randomized-controlled pilot trial, including 50 patients with amnestic cognitive impairment associated with Alzheimer's pathology, aiming to analyze the effect of physical activity and fitness on disease progression.
Dementia-MOVE is divided into two arms, of either an intervention comprising physical activity, for at least twice a week, combined with a psychoeducational program, or a sole psychoeducational program. Physical activity intervention includes a supervised and unsupervised multimodal concept combining resistance, endurance, coordinative, and aerobic training. The primary outcome is the change of brain metabolism due to physical interventional treatment. Besides metabolic magnetic resonance imaging (MRI) including sodium and phosphorus imaging, resting state functional MRI, T1-, T2-weighted and fluid-attenuated inversion recovery (FLAIR), as well as diffusion-weighted imaging (DWI) of the brain and whole-body fat MRI are performed before and after intervention, and will be compared in their sensitivity for the detection of intervention effects. We further assess cognitive performance, neuropsychiatric symptoms, quality of life, fitness, and sleep via questionnaires/interviews and/or fitness trackers, as well as microbiome, under the aspect of Alzheimer's pathology.
The aim of Dementia-MOVE is to investigate the effect of a multimodal exercise program on Alzheimer's pathology under different aspects of the disease. In this context, one of the main aims is the comparison of different MRI methods regarding their responsiveness for the detection of alterations induced by physical activity. As an underlying goal, new treatment and diagnostic options, as well as the exploration of fitness effects on brain structure and metabolism within a whole-body perspective of Alzheimer's disease are envisaged.
体育活动已显示出对衰老和神经退行性变有积极影响，并且是认知衰退的一种可能治疗选择。然而，其潜在机制以及对脑病理学的影响仍不清楚。痴呆症运动（运动的多目标验证）是一项随机对照试验，包括50名患有与阿尔茨海默病病理学相关的遗忘性认知障碍患者，旨在分析体育活动和体能对疾病进展的影响。
痴呆症运动分为两组，一组是包括每周至少两次体育活动并结合心理教育项目的干预组，另一组是单纯心理教育项目组。体育活动干预包括一个结合抗阻、耐力、协调性和有氧训练的有监督和无监督的多模式方案。主要结局是物理干预治疗导致的脑代谢变化。除了包括钠和磷成像的代谢磁共振成像（MRI）、静息态功能MRI、T1加权、T2加权和液体衰减反转恢复（FLAIR），以及脑部扩散加权成像（DWI）和全身脂肪MRI在干预前后进行检查，并将比较它们在检测干预效果方面的敏感性。我们还通过问卷/访谈和/或健身追踪器以及微生物组，在阿尔茨海默病病理学方面评估认知表现、神经精神症状、生活质量、体能和睡眠。
痴呆症运动的目的是在疾病的不同方面研究多模式运动方案对阿尔茨海默病病理学的影响。在此背景下，主要目的之一是比较不同MRI方法在检测由体育活动引起的改变方面的反应性。作为一个潜在目标，设想了新的治疗和诊断选择，以及在阿尔茨海默病的全身视角内探索体能对脑结构和代谢的影响。
