Sukhram Shiryn D, Zarini Gustavo G, Shaban Lemia H, Vaccaro Joan A, Huffman Fatma G
Department of Biology, College of Staten Island, City University of New York, Staten Island, New York, NY 10314, USA.
Clinical & Scientific Research, Oxford Biomedical Technologies, West Palm Beach, FL 33404, USA.
J Pers Med. 2022 Oct 28;12(11):1777. doi: 10.3390/jpm12111777.
This study examined the association of microalbuminuria (MAU), as determined by albumin-to-creatinine ratio (ACR), with hypertension (HTN) among Turkish immigrants with type 2 diabetes (T2D) living in deprived neighborhoods of The Hague, Netherlands.
A total of 110 participants, physician-diagnosed with T2D, aged ≥ 30 years were recruited from multiple sources from The Hague, Netherlands in a cross-sectional design. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured using automated office blood pressure equipment. Urine albumin was measured by immunoturbidimetric assay. Urine creatinine was determined using the Jaffe method. MAU was defined as ACR ≥ 3.5 mg/mmol for females and/or ACR ≥ 2.5 mg/mmol for males.
MAU was present in 21% of Turkish immigrants with T2D. Adjusted logistic regression analysis indicated that the odds of having MAU were 6.6 times higher in hypertensive than those that were normotensive ( = 0.007; 95% confidence interval [CI]: 1.19, 36.4).
These findings suggest that HTN and MAU may be assessed as a standard of care for T2D management for this population. Prospective studies of diabetes outcomes are recommended to further verify these findings.
本研究调查了在荷兰海牙贫困社区生活的2型糖尿病（T2D）土耳其移民中，通过白蛋白与肌酐比值（ACR）测定的微量白蛋白尿（MAU）与高血压（HTN）之间的关联。
采用横断面设计，从荷兰海牙的多个来源招募了总共110名年龄≥30岁、经医生诊断为T2D的参与者。使用自动诊室血压设备测量收缩压（SBP）和舒张压（DBP）。采用免疫比浊法测量尿白蛋白。使用Jaffe法测定尿肌酐。MAU定义为女性ACR≥3.5mg/mmol和/或男性ACR≥2.5mg/mmol。
21%的T2D土耳其移民存在MAU。校正后的逻辑回归分析表明，高血压患者发生MAU的几率比血压正常者高6.6倍（P = 0.007；95%置信区间[CI]：1.19，36.4）。
这些发现表明，对于该人群，HTN和MAU可作为T2D管理的护理标准进行评估。建议对糖尿病结局进行前瞻性研究以进一步验证这些发现。
