Chemistry School, Universidad Autónoma de Querétaro, Querétaro 76010, Mexico.
Unidad Académica Multidisciplinaria Reynosa-Aztlán, Universidad Autónoma de Tamaulipas, Reynosa 88740, Mexico.
Int J Environ Res Public Health. 2023 Mar 1;20(5):4418. doi: 10.3390/ijerph20054418.
There is an increasing interest in developing natural herb-infused functional beverages with health benefits; therefore, in this study, we aimed to evaluate the effect of strawberry, blueberry, and strawberry-blueberry blend decoction-based functional beverages on obesity-related metabolic alterations in high-fat and high-fructose diet-fed rats. The administration of the three berry-based beverages for eighteen weeks prevented the development of hypertriglyceridemia in obese rats (1.29-1.78-fold) and hepatic triglyceride accumulation (1.38-1.61-fold), preventing the development of hepatic steatosis. Furthermore, all beverages significantly down-regulated hepatic expression, whereas the strawberry beverage showed the greatest down-regulation of , involved in fatty acid de novo synthesis. Moreover, the strawberry beverage showed the most significant up-regulation of hepatic and (fatty acid β-oxidation). In contrast, the blueberry beverage showed the most significant down-regulation of hepatic and (fatty acid intracellular transport). Nevertheless, no beneficial effect was observed on biometric measurements, adipose tissue composition, and insulin resistance. On the other hand, several urolithins and their derivatives, and other urinary polyphenol metabolites were identified after the strawberry-based beverages supplementation. In contrast, enterolactone was found significantly increase after the intake of blueberry-based beverages. These results demonstrate that functional beverages elaborated with berry fruits prevent diet-induced hypertriglyceridemia and hepatic steatosis by modulating critical genes involved in fatty acid hepatic metabolism.
人们越来越感兴趣的是开发具有健康益处的天然草药功能饮料；因此，在这项研究中，我们旨在评估基于草莓、蓝莓和草莓蓝莓混合汤的功能性饮料对高脂肪高果糖饮食喂养大鼠肥胖相关代谢改变的影响。三种基于浆果的饮料给药十八周可预防肥胖大鼠的高甘油三酯血症（1.29-1.78 倍）和肝甘油三酯蓄积（1.38-1.61 倍），从而预防肝脂肪变性。此外，所有饮料均显著下调了肝脏的表达，而草莓饮料则表现出最强的下调作用，涉及脂肪酸从头合成。此外，草莓饮料表现出最显著的上调作用。另一方面，在摄入基于蓝莓的饮料后，发现了几种原儿茶酸及其衍生物和其他尿多酚代谢物。相反，在摄入蓝莓饮料后，发现肠内酯显著增加。这些结果表明，用浆果制成的功能性饮料通过调节参与脂肪酸肝代谢的关键基因，可预防饮食诱导的高甘油三酯血症和肝脂肪变性。
