Facultad de Enfermería y Nutriología, Universidad Autónoma de Chihuahua, C. Escorza No. 900 Centro, Chihuahua 31000, Chihuahua, Mexico.
Instituto Nacional de Salud Pública, Av. Universidad No. 655, Col. Santa Maria Ahuacatitlán, Cuernavaca 62100, Morelos, Mexico.
Int J Environ Res Public Health. 2023 Mar 3;20(5):4495. doi: 10.3390/ijerph20054495.
Ambient air pollution is a major global public health concern; little evidence exists about the effects of short-term exposure to ozone on components of metabolic syndrome in young obese adolescents. The inhalation of air pollutants, such as ozone, can participate in the development of oxidative stress, systemic inflammation, insulin resistance, endothelium dysfunction, and epigenetic modification. Metabolic alterations in blood in components of metabolic syndrome (MS) and short-term ambient air ozone exposure were determined and evaluated longitudinally in a cohort of 372 adolescents aged between 9 to 19 years old. We used longitudinal mixed-effects models to evaluate the association between ozone exposure and the risk of components of metabolic syndrome and its parameters separately, adjusted using important variables. We observed statistically significant associations between exposure to ozone in tertiles in different lag days and the parameters associated with MS, especially for triglycerides (20.20 mg/dL, 95% CI: 9.5, 30.9), HDL cholesterol (-2.56 mg/dL (95% CI: -5.06, -0.05), and systolic blood pressure (1.10 mmHg, 95% CI: 0.08, 2.2). This study supports the hypothesis that short-term ambient air exposure to ozone may increase the risk of some components of MS such as triglycerides, cholesterol, and blood pressure in the obese adolescent population.
大气污染是一个主要的全球公共卫生关注点；关于短期暴露于臭氧对肥胖青少年代谢综合征成分的影响，证据很少。吸入空气污染物，如臭氧，可能会参与氧化应激、全身炎症、胰岛素抵抗、血管内皮功能障碍和表观遗传修饰的发展。在一个由 372 名年龄在 9 至 19 岁之间的青少年组成的队列中，我们确定了代谢综合征 (MS) 成分的血液代谢变化，并在短期环境臭氧暴露后进行了纵向评估。我们使用纵向混合效应模型来评估臭氧暴露与代谢综合征成分及其参数的风险之间的关联，分别进行了重要变量的调整。我们观察到在不同滞后天数的臭氧暴露三分位数之间存在统计学显著关联，与 MS 相关的参数，特别是甘油三酯 (20.20mg/dL，95%CI：9.5，30.9)、高密度脂蛋白胆固醇 (-2.56mg/dL (95%CI：-5.06，-0.05)和收缩压 (1.10mmHg，95%CI：0.08，2.2)。这项研究支持了这样一种假设，即短期环境大气臭氧暴露可能会增加肥胖青少年人群中某些 MS 成分的风险，如甘油三酯、胆固醇和血压。
