Hannover Medical School, Department of Trauma Surgery, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Int J Mol Sci. 2023 Mar 2;24(5):4831. doi: 10.3390/ijms24054831.
Bone marrow-derived mesenchymal stem cells (BMSCs) are promising candidates for cell-based therapies. Growing evidence has indicated that overweight/obesity can change the bone marrow microenvironment, which affects some properties of BMSCs. As the overweight/obese population rapidly increases, they will inevitably become a potential source of BMSCs for clinical application, especially when receiving autologous BMSC transplantation. Given this situation, the quality control of these cells has become particularly important. Therefore, it is urgent to characterize BMSCs isolated from overweight/obese bone marrow environments. In this review, we summarize the evidence of the effects of overweight/obesity on the biological properties of BMSCs derived from humans and animals, including proliferation, clonogenicity, surface antigen expression, senescence, apoptosis, and trilineage differentiation, as well as the underlying mechanisms. Overall, the conclusions of existing studies are not consistent. Most studies demonstrate that overweight/obesity can influence one or more characteristics of BMSCs, while the involved mechanisms are still unclear. Moreover, insufficient evidence proves that weight loss or other interventions can rescue these qualities to baseline status. Thus, further research should address these issues and prioritize developing methods to improve functions of overweight- or obesity-derived BMSCs.
骨髓间充质干细胞（BMSCs）是细胞治疗有前途的候选者。越来越多的证据表明，超重/肥胖会改变骨髓微环境，从而影响 BMSCs 的某些特性。随着超重/肥胖人群的迅速增加，他们将不可避免地成为临床应用中 BMSCs 的潜在来源，尤其是在接受自体 BMSC 移植时。鉴于这种情况，这些细胞的质量控制变得尤为重要。因此，迫切需要对源自超重/肥胖骨髓环境的 BMSCs 进行特征描述。在这篇综述中，我们总结了超重/肥胖对源自人类和动物的 BMSCs 的生物学特性的影响证据，包括增殖、集落形成能力、表面抗原表达、衰老、凋亡和三系分化，以及潜在的机制。总体而言，现有研究的结论并不一致。大多数研究表明，超重/肥胖会影响 BMSCs 的一个或多个特征，而涉及的机制尚不清楚。此外，没有足够的证据证明减肥或其他干预措施可以将这些特性恢复到基线状态。因此，需要进一步研究来解决这些问题，并优先考虑开发改善超重或肥胖来源的 BMSCs 功能的方法。
