意大利子宫内膜异位症和多发性硬化症患者的流行病学和免疫特征分析
Epidemiological and Immune Profile Analysis of Italian Subjects with Endometriosis and Multiple Sclerosis.
作者信息
Zizolfi Brunella, Foreste Virginia, Bonavita Simona, Rubino Valentina, Ruggiero Giuseppina, Brescia Morra Vincenzo, Lanzillo Roberta, Carotenuto Antonio, Boscia Francesca, Taglialatela Maurizio, Guida Maurizio
机构信息
Department of Public Health, University of Naples Federico II, 80131 Naples, Italy.
Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, 80138 Naples, Italy.
出版信息
J Clin Med. 2023 Mar 4;12(5):2043. doi: 10.3390/jcm12052043.
OBJECTIVE
To report for the first time an Italian epidemiological analysis of the prevalence of multiple sclerosis (MS) in patients with endometriosis (EMS), through the study of the endometriosis population of our referral center; to analyze the clinical profile and perform a laboratory analysis to examine the immune profile and the possible correlation to other autoimmune diseases of the enrolled patients.
METHODS
We evaluated 1652 women registered with EMS in the University of Naples Federico II and retrospectively searched patients with a co-diagnosis of MS. Clinical features of both conditions were recorded. Serum autoantibody and immune profiles were analyzed.
RESULTS
9 out of 1652 patients presented a co-diagnosis of EMS and MS (9/1652 = 0.005%). Clinically, EMS and MS presented in mild forms. Hashimoto's thyroiditis was found in two patients (2/9). Even if not statistically significant, a trend of variation in CD4- CD8 T lymphocytes and of B cells were found.
CONCLUSION
Our findings suggest an increased risk of MS in women with EMS. However, large-scale prospective studies are needed.
目的
通过对我们转诊中心的子宫内膜异位症（EMS）患者群体进行研究，首次报告意大利关于子宫内膜异位症患者多发性硬化症（MS）患病率的流行病学分析；分析临床特征，并进行实验室分析，以检查入组患者的免疫特征以及与其他自身免疫性疾病的可能相关性。
方法
我们评估了那不勒斯费德里科二世大学登记患有EMS的1652名女性，并回顾性搜索了同时诊断为MS的患者。记录了两种疾病的临床特征。分析了血清自身抗体和免疫特征。
结果
1652名患者中有9名同时诊断为EMS和MS（9/1652 = 0.005%）。临床上，EMS和MS均表现为轻度形式。两名患者（2/9）患有桥本甲状腺炎。即使无统计学意义，但发现CD4 - CD8 T淋巴细胞和B细胞有变化趋势。
结论
我们的研究结果表明，患有EMS的女性患MS的风险增加。然而，需要进行大规模的前瞻性研究。
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